Kemp E, Dieperink H, Jensenius J C, Koch C, Larsen S, Madsen H H, Nielsen B, Starklint H, Steinbrüchel D A
Institute of Pathology, Odense University Hospital, Denmark.
Scand J Urol Nephrol. 1990;24(1):79-80. doi: 10.3109/00365599009180365.
Hamster hearts were transplanted to rats, and the effects of combinations of total lymphoid irradiation (TLI), cyclophosphamide, cyclosporine A (CyA) and monoclonal antibodies (MAB) were investigated. Controls not immunosuppressed rejected their xenograft in 3 to 5 days, while combination immunosuppression including MABs against CD4 or IL-2-receptors extended graft survival significantly. In one case, the graft was still functioning 180 days after transplantation, which is the longest survival seen in this model. The use of specific MABs may open a new era for both xeno- and allo-transplantation.
将仓鼠心脏移植到大鼠体内，研究了全身淋巴照射（TLI）、环磷酰胺、环孢素A（CyA）和单克隆抗体（MAB）联合使用的效果。未进行免疫抑制的对照组在3至5天内排斥异种移植心脏，而包括抗CD4或白细胞介素-2受体单克隆抗体的联合免疫抑制显著延长了移植物存活时间。在一个病例中，移植后180天移植物仍在发挥功能，这是该模型中观察到的最长存活时间。特异性单克隆抗体的应用可能为异种移植和同种异体移植开创一个新时代。
