Sköld Ulla Moberg, Birkhed Dowen, Ellwood Roger
Department of Cariology, Institute of Odontology Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
J Clin Dent. 2012;23(3):97-100.
The aim of the present study was to evaluate the effects on post-brushing salivary F retention of rinsing with mouthwashes containing either 500 or 225 ppm F compared to not rinsing.
The study was a randomized, investigator-blind, cross-over trial with three treatment arms. Thirty volunteers brushed with 0.5 g of 1450 ppm F paste for 40 seconds and then spat out the waste slurry. They then rinsed for one minute with 10 mL of their allocated mouthwash or they did not rinse after the brushing. Saliva samples were collected before brushing (0 minutes) and at one, three, five, 10, 20, 30, 45, and 60 minutes after brushing. The subjects were not allowed to speak, eat, or drink during these 60-minute test periods. The F levels in saliva were then calculated for each time point and the integrated area under the curve calculated (AUC0-60).
The mean AUCs were 626, 380, and 237 for the 500 ppm F, 225 ppm F, and no rinse treatments, respectively, and all pair-wise comparisons were statistically significant (p < 0.01).
It is concluded that rinsing with either 500 or 225 ppm F mouthwash significantly increases the level of F in saliva compared to not rinsing after brushing with 1450 ppm F toothpaste. The 500 ppm F mouthwash provided a significant increase in F retention compared to the 225 ppm F rinse (p = 0.001).
本研究旨在评估与不冲洗相比，使用含500 ppm或225 ppm氟的漱口水冲洗对刷牙后唾液中氟保留量的影响。
该研究是一项随机、研究者盲法、交叉试验，有三个治疗组。30名志愿者用0.5 g含1450 ppm氟的牙膏刷牙40秒，然后吐出残留牙膏。之后，他们用10 mL分配的漱口水冲洗1分钟，或者刷牙后不冲洗。在刷牙前（0分钟）以及刷牙后1、3、5、10、20、30、45和60分钟收集唾液样本。在这60分钟的测试期间，受试者不得说话、进食或饮水。然后计算每个时间点唾液中的氟含量，并计算曲线下的积分面积（AUC0 - 60）。
500 ppm氟、225 ppm氟和不冲洗处理的平均AUC分别为626、380和237，所有两两比较均具有统计学意义（p < 0.01）。
得出的结论是，与用1450 ppm氟牙膏刷牙后不冲洗相比，使用500 ppm或225 ppm氟漱口水冲洗可显著提高唾液中的氟含量。与225 ppm氟漱口水冲洗相比，500 ppm氟漱口水能显著提高氟的保留量（p = 0.001）。
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