Cooper L, Komarov G N, Shaw K E, Pretty I A, Ellwood R P, Birkhed D, Smith P W, Flannigan N L, Higham S M
Department of Health Services Research and School of Dentistry, University of Liverpool, UK.
J Clin Dent. 2012;23(3):92-6.
This study evaluated the effects of three post-brushing mouthwashes containing 0 ppm F, 225 ppm F, and 500 ppm F, respectively, on salivary fluoride retention after brushing with 1450 ppm fluoride (as NaF) toothpaste and rinsing with water immediately after brushing.
In this three-phase, randomized, cross-over study, an ion-specific electrode was used to measure salivary F levels in thirty trial participants before brushing (Time 0), and after brushing, rinsing with water, and then rinsing with one of the three mouthwashes. Time points evaluated after brushing were one, three, five, 10, 20, 30, 45, and 60 minutes. For saliva sample collections, subjects were asked to pool saliva in their mouths for 10 seconds before spitting out into a container for each of the time points.
The AUC0-60 means for F in saliva were 554, 252, and 20 for the 500, 225, and 0 ppm F mouthwash groups, respectively. The 500 ppm F mouthwash resulted in a 2660% increase in total fluoride salivary retention over 60 minutes when compared with the 0 ppm F group, and a 120% increase when compared with the 225 ppm F group. A significant difference (p < 0.001) in the AUC0-60 means between the three groups was observed using analysis of variance (ANOVA). Paired t-tests also showed significant differences in the mean fluoride retention over 60 minutes for all three pair-wise group comparisons (p < 0.001).
Use of a fluoride mouthwash containing 225 ppm F or 500 ppm F produced a significant increase in salivary fluoride retention following brushing with a 1450 ppm F toothpaste and rinsing with water compared to rinsing without fluoride. The use of the 500 ppm F mouthwash may be of particular benefit to those at high caries risk.
本研究评估了三种分别含有0 ppm氟、225 ppm氟和500 ppm氟的刷牙后漱口水，在使用含1450 ppm氟（以氟化钠计）牙膏刷牙并立即用水冲洗后，对唾液氟保留量的影响。
在这项三阶段、随机、交叉研究中，使用离子特异性电极测量30名试验参与者在刷牙前（时间0）、刷牙后、用水冲洗后以及用三种漱口水之一冲洗后的唾液氟水平。刷牙后评估的时间点为1、3、5、10、20、30、45和60分钟。对于唾液样本采集，要求受试者在每个时间点将唾液在口中汇集10秒，然后吐入容器中。
500 ppm氟漱口水组、225 ppm氟漱口水组和0 ppm氟漱口水组唾液中氟的AUC0 - 60均值分别为554、252和20。与0 ppm氟组相比，500 ppm氟漱口水在60分钟内使唾液中总氟保留量增加了2660%，与225 ppm氟组相比增加了120%。使用方差分析（ANOVA）观察到三组之间的AUC0 - 60均值存在显著差异（p < 0.001）。配对t检验也显示，在所有三种两两分组比较中，60分钟内氟保留量的均值存在显著差异（p < 0.001）。
与不使用含氟漱口水冲洗相比，使用含225 ppm氟或500 ppm氟的漱口水在使用1450 ppm氟牙膏刷牙并用水冲洗后，能显著增加唾液氟保留量。使用500 ppm氟漱口水可能对高龋齿风险人群特别有益。
