FCPS Haematology, Department of Pathology and Microbiology, The Aga Khan University and Hospital, Karachi, Pakistan.
Exp Hematol Oncol. 2012 May 18;1(1):13. doi: 10.1186/2162-3619-1-13.
We present our initial experience of allogeneic stem cell transplant procedure performed between April 2004 and August 2011 for various haematological disorders. All patients with non-malignant and malignant haematological disorders with HLA matched donors were selected after pre-transplant workup. Ninety seven patients underwent the procedure. Most common indications for transplant were aplastic anaemia in n = 34 (35%), followed by β-Thalassemia major in n = 21 (21.6%) and chronic myeloid leukemia in n = 11 patients (11.3%). Primary graft failure present was present in 2.06%. Incidence of graft versus host disease (GvHD) in our patients was 34%. After median follow-up of five years the overall survival was 71.3% with a mean survival time of 51.2 ± 3.3 months.
我们介绍了 2004 年 4 月至 2011 年 8 月期间为各种血液系统疾病进行同种异体干细胞移植手术的初步经验。所有非恶性和恶性血液系统疾病且与 HLA 匹配的供者均在移植前检查后被选中。97 名患者接受了该手术。移植最常见的适应证是 34 例（35%）再生障碍性贫血，其次是 21 例（21.6%）β-地中海贫血和 11 例（11.3%）慢性髓性白血病。原发性移植物失败的发生率为 2.06%。我们的患者中移植物抗宿主病（GVHD）的发生率为 34%。中位随访 5 年后，总生存率为 71.3%，平均生存时间为 51.2±3.3 个月。
