Khanlari Mahsa, Bagheri Babak, Vojdani Reza, Mohammadianpanah Mohammad, Paydar Shahram, Daneshbod Yahya
Institute of Hematopathology, Dr Daneshbod Pathology Laboratory, Shiraz, Iran.
BMC Res Notes. 2012 Dec 4;5:671. doi: 10.1186/1756-0500-5-671.
To describe a rare manifestation of mantle cell lymphoma (MCL) in conjunctiva, with clinical, hisologic, immunohistologic and genetic findings together with review of the Literature.
Most ocular adnexal lymphomas are extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT). A few cases of ocular adnexal mantle cell lymphomas have been reported in the literature. We present a case of mantle cell lymphoma presenting as right conjunctival mass of at least three months duration in a 64-year-old man. Histopathologic examination showed a proliferation of monomorphous small-to-medium-sized lymphoid cells with cleaved nuclei in the subconjunctiva. By immunohistochemistry, the infiltrate was positive for CD20, CD5, BCL-2, cyclin D1, and the transcription factor SOX11. Fluorescent in situ hybridization demonstrated the presence of IGH-CCND1 fusion indicating t(11;14).
A rigorous approach to initial diagnosis and staging of small cell lymphomas of the ocular adnexa is needed. The recognition of ocular MCL requires appropriate immunohistochemical staining and/or genetic confirmation to differentiate this rare form of presentation of MCL from other more frequent small cell lymphomas.
描述结膜套细胞淋巴瘤（MCL）的一种罕见表现，包括临床、组织学、免疫组织化学和遗传学发现，并复习相关文献。
大多数眼附属器淋巴瘤是黏膜相关淋巴组织（MALT）的结外边缘区B细胞淋巴瘤。文献中已报道了少数几例眼附属器套细胞淋巴瘤病例。我们报告一例64岁男性患者，其右侧结膜肿物至少持续3个月，病理诊断为套细胞淋巴瘤。组织病理学检查显示结膜下有单形性中小淋巴细胞增殖，细胞核有裂沟。免疫组织化学检查显示浸润细胞CD20、CD5、BCL-2、细胞周期蛋白D1及转录因子SOX11均呈阳性。荧光原位杂交显示存在IGH-CCND1融合，提示t(11;14)。
对于眼附属器小细胞淋巴瘤的初始诊断和分期需要采取严谨的方法。眼MCL的诊断需要适当的免疫组织化学染色和/或基因确认，以将这种罕见的MCL表现形式与其他更常见的小细胞淋巴瘤区分开来。
