School of Health Sciences, University of Tampere, Tampere, Finland.
Eur J Clin Nutr. 2012 Dec;66(12):1344-50. doi: 10.1038/ejcn.2012.146.
Healthy diet, physical activity and modest weight gain during pregnancy may prevent developing gestational diabetes mellitus (GDM). We examined whether a lifestyle intervention designed to prevent GDM was effective in reducing excessive gestational weight gain (GWG).
A cluster-randomised controlled trial (n=399) was conducted in maternity clinics in 14 municipalities in Southern Finland. Pregnant women with at least one risk factor for GDM (for example, overweight) but no pre-existing diabetes were recruited at 8-12 weeks' gestation. The intervention included counselling on GWG, physical activity and healthy eating at five routine visits. Usual counselling practices were continued in the usual care municipalities. Statistical analyses were performed using multilevel linear and logistic regression models adjusted for weeks' gestation at last weight measurement, pre-pregnancy body mass index and smoking status.
The intervention group had a lower mean GWG by weeks' gestation than the usual care group (adjusted coefficient for the between-group difference -0.016 kg per day, P=0.041). There was no difference in mean (± s.d.) GWG between the intervention and the usual care groups (13.7 ± 5.8 vs 14.3 ± 5.0 kg, P=0.64). In total, 46.8% of the intervention group and 54.4% of the usual care group exceeded the GWG recommendations. The adjusted odds ratio for excessive GWG was 0.82 (95% CI 0.53-1.26, P=0.36) in the intervention group as compared with the usual care group.
The intervention had minor effects on GWG among women who were at increased risk for GDM. In order to prevent excessive GWG, additional focus on restriction of energy intake may be needed.
健康饮食、身体活动和适度的孕期增重可预防妊娠糖尿病(GDM)的发生。我们研究了旨在预防 GDM 的生活方式干预是否可有效减少孕期体重过度增加(GWG)。
在芬兰南部 14 个市的产科诊所进行了一项群组随机对照试验(n=399)。在妊娠 8-12 周时,招募了至少有一个 GDM 风险因素(例如超重)但无既往糖尿病的孕妇。该干预包括在五次常规就诊时对 GWG、身体活动和健康饮食进行咨询。在常规护理市继续进行常规咨询。使用多水平线性和逻辑回归模型进行统计分析,模型调整了末次体重测量时的孕周、孕前体重指数和吸烟状况。
干预组的 GWG 均值随着孕周的增加低于常规护理组(组间差异的调整系数为每天-0.016kg,P=0.041)。干预组和常规护理组的 GWG 均值(±s.d.)无差异(分别为 13.7±5.8kg 和 14.3±5.0kg,P=0.64)。干预组和常规护理组中,分别有 46.8%和 54.4%的孕妇体重增加超过 GWG 推荐量。与常规护理组相比,干预组 GWG 过多的调整后比值比为 0.82(95%CI 0.53-1.26,P=0.36)。
对于有 GDM 风险增加的女性,该干预对 GWG 仅有轻微影响。为了预防 GWG 过多,可能需要额外关注能量摄入的限制。