CASP-10基因多态性在癌症易感性中的作用：一项HuGE综述与荟萃分析

Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE review and meta-analysis.

作者信息

Yan S, Li Y Z, Zhu J W, Liu C L, Wang P, Liu Y L

机构信息

Department of Urological Surgery, Fourth Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.

出版信息

Genet Mol Res. 2012 Nov 26;11(4):3998-4007. doi: 10.4238/2012.November.26.1.

DOI:10.4238/2012.November.26.1

PMID:23212337

Abstract

We investigated a possible association between CASP-10 gene polymorphisms and susceptibility to cancer through a meta-analysis. Eight studies with a total of 29,936 cancer cases and 34,041 healthy controls were included. Meta-analysis results showed that the rs13006529 T carrier was significantly associated with increased cancer risk (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). However, rs3900115 and rs13010627 showed no association with cancer susceptibility (all P > 0.05). In the subgroup analysis by cancer type, we found that the rs13006529 T carrier was a risk factor for breast cancer (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). Similarly, no association was found between CASP-10 polymorphisms and susceptibility to lymphoma, myeloma, melanoma, or lung cancer (all P > 0.05). This meta-analysis suggests that the rs13006529 T carrier in the CASP-10 gene might be a risk factor for cancer susceptibility, especially for breast cancer.

摘要

我们通过一项荟萃分析研究了半胱天冬酶-10（CASP-10）基因多态性与癌症易感性之间的可能关联。纳入了八项研究，共计29936例癌症病例和34041例健康对照。荟萃分析结果显示，rs13006529 T携带者与癌症风险增加显著相关（OR = 1.17，95%CI = 1.01-1.36，P = 0.03）。然而，rs3900115和rs13010627与癌症易感性无关联（所有P>0.05）。在按癌症类型进行的亚组分析中，我们发现rs13006529 T携带者是乳腺癌的一个危险因素（OR = 1.17，95%CI = 1.01-1.36，P = 0.03）。同样，未发现CASP-10多态性与淋巴瘤、骨髓瘤、黑色素瘤或肺癌易感性之间存在关联（所有P>0.05）。这项荟萃分析表明，CASP-10基因中的rs13006529 T携带者可能是癌症易感性的一个危险因素，尤其是对于乳腺癌。