Department of Diagnosis of Chinese Medicine, School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing, China.
Chin J Integr Med. 2013 Feb;19(2):92-7. doi: 10.1007/s11655-012-1214-8. Epub 2012 Dec 3.
To investigate the potential of renal pathological index as a differential diagnosis factor for Chinese medicine (CM) syndromes typing in IgA nephropathy (IgAN).
A total of 1,016 patients with IgAN was recruited from November 2001 to November 2004. All the signs and symptoms including picture of the tongue and pulse tracings were collected. All patients were typed according to the CM syndrome typing scheme for chronic primary glomerulopathy. The severity of glomerulus and tubulointerstitial lesions (mild, moderate-severe) were evaluated using lee's grading system and the Katafuchi score system.
The syndrome types transform in turn by deficiency of both the Spleen (Pi) and Lung (Fei) qi, deficiency of both qi and yin, deficiency of Liver (Gan) and Kidney (Shen) yin and deficiency of Spleen-Kidney (Shen) yang, with the aggravation of pathogenetic condition and that the manifestation of deficiency of qi clinically showed proliferative lesion of glomerular mesangium, while the glomerular sclerosis pathologically showed the manifestation of yin deficiency.
Renal pathological findings may be a candidate of objective factors to refine CM syndrome typing process.
探讨肾脏病理指标作为 IgA 肾病（IgAN）中医辨证分型的鉴别诊断因素的潜力。
2001 年 11 月至 2004 年 11 月共纳入 1016 例 IgAN 患者。收集所有症状和体征，包括舌象和脉象。所有患者均根据慢性原发性肾小球病的中医辨证分型方案进行分型。肾小球和肾小管间质病变的严重程度（轻度、中重度）采用 Lee 分级系统和 Katafuchi 评分系统进行评估。
证型依次转化为肺脾气虚、气阴两虚、肝肾阴虚和脾肾两虚，随着病情的加重，临床表现为气虚，肾小球系膜增生性病变，病理表现为阴虚。
肾脏病理表现可能是中医辨证分型过程中客观因素的候选指标。
