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乳头雷诺现象与拉贝洛尔的使用有关。

Raynaud's phenomenon of the nipple associated with labetalol use.

机构信息

Department of Obstetrics and Gynaecology, St Helens and Knowsley Teaching Hospital, Prescot, UK.

出版信息

J Hum Lact. 2013 Feb;29(1):17-9. doi: 10.1177/0890334412467509. Epub 2012 Dec 4.

DOI:10.1177/0890334412467509
PMID:23212937
Abstract

Raynaud's phenomenon of the nipple is an unusual cause of severe nipple pain. Precipitants for Raynaud's phenomenon of the nipple are known to be cold temperatures, caffeine, and emotional stress. Nipple pain is quoted as the most common cause of cessation of breastfeeding. It is important that lactation consultants and other health care professionals are aware of Raynaud's phenomenon of the nipple and the treatment options available. This is a case of a 37-year-old woman, Gravida 2, Para 1, who was first seen in the antenatal clinic at 34 weeks gestation. A diagnosis of Raynaud's phenomenon of the nipple was made after she began taking labetalol for pregnancy-induced hypertension. The phenomenon had occurred in both of her previous pregnancies on commencing labetalol and resolved postnatally on cessation of the drug. We aim to raise awareness of both the condition itself and the potential role of labetalol in the development of Raynaud's phenomenon of the nipple.

摘要

乳头雷诺现象是一种引起严重乳头疼痛的不常见原因。已知引起乳头雷诺现象的诱因有寒冷温度、咖啡因和情绪压力。乳头疼痛是导致停止母乳喂养的最常见原因。哺乳期顾问和其他保健专业人员了解乳头雷诺现象及其可用的治疗选择非常重要。这是一位 37 岁女性的病例,孕 2 产 1,在 34 周妊娠时首次在产前诊所就诊。在开始服用拉贝洛尔治疗妊娠高血压后,她出现了这种现象,随后被诊断为乳头雷诺现象。这种现象在她之前的两次妊娠中都发生过,在开始服用拉贝洛尔时出现,在产后停止用药后消失。我们旨在提高对这种情况本身以及拉贝洛尔在乳头雷诺现象发展中的潜在作用的认识。

相似文献

1
Raynaud's phenomenon of the nipple associated with labetalol use.乳头雷诺现象与拉贝洛尔的使用有关。
J Hum Lact. 2013 Feb;29(1):17-9. doi: 10.1177/0890334412467509. Epub 2012 Dec 4.
2
Raynaud's phenomenon of the nipple: a treatable cause of painful breastfeeding.乳头雷诺现象:母乳喂养疼痛的一个可治疗病因。
Pediatrics. 2004 Apr;113(4):e360-4. doi: 10.1542/peds.113.4.e360.
3
Raynaud's phenomenon of the nipple as a side-effect of labetalol: Case report and literature review.作为拉贝洛尔副作用的乳头雷诺现象:病例报告及文献综述
Case Rep Womens Health. 2019 Jul 24;23:e00135. doi: 10.1016/j.crwh.2019.e00135. eCollection 2019 Jul.
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[Repeated attacks of pain in the nipple of a pregnant woman. Unusual manifestation of Raynaud's phenomenon].[孕妇乳头反复疼痛发作。雷诺现象的不寻常表现]
Dtsch Med Wochenschr. 2003 Sep 5;128(36):1825-8. doi: 10.1055/s-2003-41967.
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Nipple pain: Raynaud's beyond fingers and toes.乳头疼痛:雷诺现象不仅限于手指和脚趾。
Breast J. 2020 Oct;26(10):2045-2047. doi: 10.1111/tbj.13991. Epub 2020 Aug 4.
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Raynaud's phenomenon of the nipple during breastfeeding: A case series.哺乳期乳头雷诺现象:病例系列。
Arch Argent Pediatr. 2024 Oct 1;122(5):e202310280. doi: 10.5546/aap.2023-10280.eng. Epub 2024 May 23.
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Raynaud's phenomenon of the nipples: an elusive diagnosis.乳头雷诺现象:一种难以捉摸的诊断。
J Hum Lact. 2007 May;23(2):191-3. doi: 10.1177/0890334407300018.
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Labetalol for hypertension during pregnancy and nipple pain.拉贝洛尔用于妊娠期高血压及乳头疼痛。
Eur J Obstet Gynecol Reprod Biol. 2014 Nov;182:254-5. doi: 10.1016/j.ejogrb.2014.09.041. Epub 2014 Oct 6.
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[Diagnostic image. A breastfeeding woman with a painful, blue nipple].[诊断图像。一位哺乳期妇女,乳头疼痛且呈蓝色]
Ned Tijdschr Geneeskd. 2009;153:B343.
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Raynaud's Phenomenon of the Nipple: Epidemiological, Clinical, Pathophysiological, and Therapeutic Characterization.乳头雷诺现象:流行病学、临床、病理生理和治疗特征。
Int J Environ Res Public Health. 2024 Jun 28;21(7):849. doi: 10.3390/ijerph21070849.

引用本文的文献

1
Safety and Risks of Antihypertensive Medications During Breastfeeding: A Review of Current Guidelines.母乳喂养期间抗高血压药物的安全性与风险:现行指南综述
J Clin Med. 2025 May 26;14(11):3722. doi: 10.3390/jcm14113722.
2
Raynaud's Phenomenon of the Nipple: Epidemiological, Clinical, Pathophysiological, and Therapeutic Characterization.乳头雷诺现象:流行病学、临床、病理生理和治疗特征。
Int J Environ Res Public Health. 2024 Jun 28;21(7):849. doi: 10.3390/ijerph21070849.
3
Labetalol-Associated Raynaud's Phenomenon of the Nipple: A Rare Case Report with Review of Literature.
拉贝洛尔相关的乳头雷诺现象:一例罕见病例报告并文献复习
J Obstet Gynaecol India. 2022 Dec;72(6):533-535. doi: 10.1007/s13224-022-01708-w. Epub 2022 Oct 21.
4
Postpartum Nipple Symptoms: Risk Factors and Dermatologic Characterization.产后乳头症状:危险因素和皮肤特征。
Breastfeed Med. 2021 Mar;16(3):215-221. doi: 10.1089/bfm.2020.0030. Epub 2020 Dec 18.
5
Raynaud's phenomenon of the nipple as a side-effect of labetalol: Case report and literature review.作为拉贝洛尔副作用的乳头雷诺现象:病例报告及文献综述
Case Rep Womens Health. 2019 Jul 24;23:e00135. doi: 10.1016/j.crwh.2019.e00135. eCollection 2019 Jul.
6
Nipple pain, damage, and vasospasm in the first 8 weeks postpartum.产后8周内的乳头疼痛、损伤及血管痉挛。
Breastfeed Med. 2014 Mar;9(2):56-62. doi: 10.1089/bfm.2013.0106. Epub 2013 Dec 31.