Shirai M, Maki A, Takanami M, Ando K, Nakamura K, Yanaihara N, Yanaihara C, Iguchi K, Fujita T, Iwanaga T
Department of Urology, Toho University School of Medicine, Tokyo, Japan.
Urology. 1990 Apr;35(4):360-3. doi: 10.1016/0090-4295(90)80166-k.
Penile erection is controlled by a valvular structure in the helicine artery in humans. The opening and closing of this valve are believed to be regulated by the autonomic nervous system, especially through the release of vasoactive intestinal polypeptide (VIP). We determined the content of VIP in cavernous tissue in 18 impotent patients and in 5 normal controls by radioimmunoassay, and we examined the distribution of VIP-ergic nerve fibers in cavernous tissue by an immunohistochemical method. As a result, it was found that the lower penile VIP content was more frequent among patients with organic impotence than among the controls. Furthermore, VIP-ergic nerve fibers were seen to be diffusely and loosely distributed in a large number of organic impotence patients. These findings suggest that organic impotence in some patients may be due to decreases in the VIP content and in VIP-ergic nerve fibers.
在人类中，阴茎勃起受螺旋动脉中的一个瓣膜结构控制。据信，该瓣膜的开闭由自主神经系统调节，特别是通过血管活性肠肽（VIP）的释放来调节。我们通过放射免疫分析法测定了18例阳痿患者和5例正常对照者海绵体组织中VIP的含量，并采用免疫组织化学方法检测了海绵体组织中含VIP神经纤维的分布。结果发现，器质性阳痿患者阴茎VIP含量低于对照组的情况更为常见。此外，在大量器质性阳痿患者中，可见含VIP神经纤维呈弥漫性、松散分布。这些发现表明，部分患者的器质性阳痿可能是由于VIP含量及含VIP神经纤维减少所致。
