Kimura Tetsuya, Okamoto Yasuyuki
Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University.
Nihon Rinsho. 2012 Nov;70(11):1908-12.
Graves' disease is a unique autoimmune disease with cell proliferation and excess function, caused by anti-thyrotropin receptor antibody (TRAb), and apart from antibody-mediated organ destruction seen in other autoimmune diseases. In this article, we discuss the latest progress in the research field of TRAb. The biological natures of various TRAbs are also summarized. Additionally, we introduce the development of a full-automated and rapid measurement system for TRAb. Measurement of the titer of TRAb within one hour in office setting enables clinicians to make more concrete diagnosis of Graves' disease at the first visit of patients.
格雷夫斯病是一种独特的自身免疫性疾病，具有细胞增殖和功能亢进的特点，由抗促甲状腺素受体抗体（TRAb）引起，与其他自身免疫性疾病中所见的抗体介导的器官破坏不同。在本文中，我们讨论了TRAb研究领域的最新进展。还总结了各种TRAb的生物学特性。此外，我们介绍了一种用于TRAb的全自动快速测量系统的开发。在门诊环境中一小时内测量TRAb滴度，使临床医生能够在患者首次就诊时对格雷夫斯病做出更确切的诊断。
