School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, 450001, China.
J Org Chem. 2013 Jan 18;78(2):339-46. doi: 10.1021/jo302203g. Epub 2012 Dec 18.
For the first time, the [2,3]-Meisenheimer rearrangement has been developed into a general strategy for the construction of chiral tertiary alcohols. The effectiveness and practicality of this methodology are illustrated by the successful synthesis of (R)-20 and (R)-30, the side chain acids of homoharringtonine and harringtonine, respectively.
首次将[2,3]-Meisenheimer 重排反应发展成一种构建手性叔醇的通用策略。该方法的有效性和实用性通过成功合成（R）-20 和（R）-30 得到了证明，这两种化合物分别是高三尖杉酯碱和高三尖杉酯碱的侧链酸。
