HIV-1 Nef 在巨噬细胞介导的疾病发病机制中的作用。
HIV-1 Nef in macrophage-mediated disease pathogenesis.
机构信息
BioInfoExperts, Thibodaux, LA, USA.
出版信息
Int Rev Immunol. 2012 Dec;31(6):432-50. doi: 10.3109/08830185.2012.737073.
Abstract
Combined anti-retroviral therapy (cART) has significantly reduced the number of AIDS-associated illnesses and changed the course of HIV-1 disease in developed countries. Despite the ability of cART to maintain high CD4+ T-cell counts, a number of macrophage-mediated diseases can still occur in HIV-infected subjects. These diseases include lymphoma, metabolic diseases, and HIV-associated neurological disorders. Within macrophages, the HIV-1 regulatory protein "Nef" can modulate surface receptors, interact with signaling pathways, and promote specific environments that contribute to each of these pathologies. Moreover, genetic variation in Nef may also guide the macrophage response. Herein, we review findings relating to the Nef-macrophage interaction and how this relationship contributes to disease pathogenesis.
摘要
联合抗逆转录病毒疗法（cART）显著降低了艾滋病相关疾病的数量，并改变了发达国家的 HIV-1 疾病进程。尽管 cART 能够维持高 CD4+ T 细胞计数，但在 HIV 感染者中仍会发生一些巨噬细胞介导的疾病。这些疾病包括淋巴瘤、代谢疾病和与 HIV 相关的神经紊乱。在巨噬细胞内，HIV-1 调节蛋白“Nef”可以调节表面受体，与信号通路相互作用，并促进每种病理发生的特定环境。此外，Nef 的遗传变异也可能指导巨噬细胞的反应。本文综述了与 Nef-巨噬细胞相互作用相关的研究结果，以及这种相互作用如何促进疾病的发病机制。
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