Tavasoli Sanaz, Eghtesadi Shahryar, Heidarnazhad Hassan, Moradi-Lakeh Maziar
Department of Nutrition and Biochemistry, Tehran University of Medical Sciences, Tehran, Iran.
J Asthma. 2013 Mar;50(2):180-7. doi: 10.3109/02770903.2012.740121. Epub 2012 Dec 5.
The potential role of central obesity in asthma outcomes has been examined in a few studies. The aim of this study was to examine the relationship between central obesity and asthma outcomes in a group of Iranian asthma patients.
One hundred and forty-two outpatients with asthma were studied. Central obesity was defined according to National Institute of Health (NIH) and Asian waist circumference (WC) and waist-to-hip ratio (WHR) cut-offs. Asthma outcomes including asthma control, pulmonary function, and morbidity were evaluated. The association between central obesity and asthma outcomes was studied by linear and logistic regression analyses.
Linear regression analysis showed a significant association of WHR-based central obesity with forced expiratory volume in 1 s (FEV(1)) (β = -9.04; p-value = .044) and forced vital capacity (FVC) (β = -10.52; p-value = .012). Logistic regression analysis showed a significant increased risk of asthma attacks in 3 months with Asian WC-based central obesity [odds ratio (OR) = 6.31, 95% confidence interval (CI): 1.16-34.41]; emergency room (ER) visits with NIH WC-based (OR = 5.15, 95% CI: 1.36-19.55) and Asian WC-based (OR = 18.72, 95% CI: 1.92-182.63) central obesity; and hospitalization in 1 year with NIH WC-based (OR = 5.28, 95% CI: 1.28-21.84) and Asian WC-based (OR = 12.39, 95% CI: 1.29-119.53) central obesity.
Our study shows that the Asian WC-based central obesity is a better predictor of asthma morbidity. The results of this study emphasize, when studying the relationship between asthma control and obesity, the importance of selecting the proper definitions for asthma control or central obesity and appropriate cutpoints. Further study in this field using other asthma control and quality of life questionnaires is warranted.
少数研究探讨了中心性肥胖在哮喘预后中的潜在作用。本研究旨在调查一组伊朗哮喘患者中中心性肥胖与哮喘预后之间的关系。
对142例哮喘门诊患者进行研究。根据美国国立卫生研究院（NIH）以及亚洲人的腰围（WC）和腰臀比（WHR）临界值定义中心性肥胖。评估哮喘预后，包括哮喘控制、肺功能和发病率。通过线性回归和逻辑回归分析研究中心性肥胖与哮喘预后之间的关联。
线性回归分析显示，基于WHR的中心性肥胖与1秒用力呼气量（FEV₁）（β = -9.04；p值 = 0.044）和用力肺活量（FVC）（β = -10.52；p值 = 0.012）显著相关。逻辑回归分析显示，基于亚洲人WC的中心性肥胖使3个月内哮喘发作风险显著增加[比值比（OR） = 6.31，95%置信区间（CI）：1.16 - 34.41]；基于NIH WC的中心性肥胖使急诊室（ER）就诊风险增加（OR = 5.15，95% CI：1.36 - 19.55），基于亚洲人WC的中心性肥胖使急诊室就诊风险增加（OR = 18.72，95% CI：1.92 - 182.63）；基于NIH WC的中心性肥胖使1年内住院风险增加（OR = 5.28，95% CI：1.28 - 21.84），基于亚洲人WC的中心性肥胖使1年内住院风险增加（OR = 12.39，95% CI：1.29 - 119.53）。
我们的研究表明，基于亚洲人WC的中心性肥胖是哮喘发病率的更好预测指标。本研究结果强调，在研究哮喘控制与肥胖之间的关系时，选择合适的哮喘控制或中心性肥胖定义及合适的切点非常重要。有必要在该领域使用其他哮喘控制和生活质量问卷进行进一步研究。
