Management of conflicts of interest in cardiovascular medicine.

Conflicts of interest (COIs) are common and important in cardiovascular medicine. Although COIs do not automatically lead to bias, conflicts between financial considerations, fame, promotion, etc., threaten valued interests such as objectivity, integrity, patient protection and cost-savings. Strategies for managing COIs include disclosure, limitations and eliminations, each of which is employed in varying degrees by universities, funding and regulatory agencies, journal editors, providers of continuing medical education and professional societies. This paper describes benefits and pitfalls inherent in each of these strategies. There is no "gold standard" for the dealing with COIs in cardiovascular medicine, but finding ways to manage unavoidable COIs without compromising the benefits of productive relationships between investigators and industry will be essential to preserving valued interests and public trust in the cardiovascular profession.