Bai R, Zhao P, Cao G, Wen S, Li Q, Meng Q
Department of Clinical Laboratory, Inner Mongolia People's Hospital, Hohhot, China.
Cell Mol Biol (Noisy-le-grand). 2012 Dec 5;58 Suppl:OL1797-802.
Ghrelin has recently garnered increasing attention in biomolecular studies. Ghrelin's growth hormone secretagogue receptor type 1a (GHS--R) is a pleiotropic modulator of diverse biological functions, including energy homeostasis and reproduction. This study sought to understand the ways in which ghrelin impacts ERK1/2 and p90rsk during the ovis aries oocyte maturation process. We applied different concentrations of ghrelin and of ghrelin receptor inhibitor (D--Lys3--GHRP--6) to ovis aries oocytes and observed the effects on the ERK1/2 and p90rsk pathway. The ERK1/2 and p90rsk pathway plays an essential role in the in vitro maturation of ovis aries oocytes. This study discovered that ERK1/2 and p90 rsk pathway, during the ovis aries oocyte maturation, was associated with maturation of ovis aries oocyte in vitro.
近年来，胃饥饿素在生物分子研究中受到越来越多的关注。胃饥饿素的1a型生长激素促分泌素受体（GHS-R）是多种生物学功能的多效调节剂，包括能量稳态和生殖。本研究旨在了解胃饥饿素在绵羊卵母细胞成熟过程中影响细胞外信号调节激酶1/2（ERK1/2）和p90核糖体S6激酶（p90rsk）的方式。我们将不同浓度的胃饥饿素和胃饥饿素受体抑制剂（D-赖氨酸3-生长激素释放肽-6）应用于绵羊卵母细胞，并观察其对ERK1/2和p90rsk信号通路的影响。ERK1/2和p90rsk信号通路在绵羊卵母细胞的体外成熟中起着至关重要的作用。本研究发现，在绵羊卵母细胞成熟过程中，ERK1/2和p90rsk信号通路与绵羊卵母细胞的体外成熟有关。
