Departments of Medicine and Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
Cell. 2012 Dec 7;151(6):1161-2. doi: 10.1016/j.cell.2012.11.031.
An accurate prediction of how extrinsic stimuli influence changes in gene expression has been challenging. In this issue, Nagano and colleagues successfully model genome-wide mRNA expression changes under variable environmental conditions in rice, raising hopes that scientists will soon be able to predict genome-wide transcriptional responses in a variety of organisms in uncontrolled real-world settings.
准确预测外在刺激如何影响基因表达的变化一直具有挑战性。在本期杂志中，Nagano 及其同事成功地对水稻在不同环境条件下的全基因组 mRNA 表达变化进行了建模，这让人们希望科学家们很快就能在不受控制的真实环境中预测各种生物体的全基因组转录反应。
