Department of Pharmaceutical and Biomedical Sciences, University of Salerno, I-84084 Fisciano (SA), Italy.
Carbohydr Polym. 2013 Jan 30;92(1):367-73. doi: 10.1016/j.carbpol.2012.09.056. Epub 2012 Oct 4.
This paper proposes a multi-particulate drug delivery system produced by prilling technique in combination with an enteric coating. Optimization of process parameters, such as feed viscosity at nozzle, selection of cross-linker, pH of the gelling solution and cross-linking time, allows to obtain beads with strong gelled matrix. Results showed that dextran/piroxicam beads demonstrated high encapsulation efficiency, very narrow dimensional distribution and high sphericity. Coated beads retained shape and narrow size distribution of the uncoated particles. Moreover, the strength of the produced Zn(2+)-pectinate beads allows to reduce Eudragit coating thickness. Piroxicam loaded multi-particulate systems show an interesting prolonged drug release in intestinal fluids. Hence, such platforms could be proposed for the treatment of inflammatory bowel diseases.
本文提出了一种由造粒技术与肠溶包衣相结合生产的多颗粒药物递送系统。通过优化工艺参数，如喷嘴处的进料黏度、交联剂的选择、胶凝溶液的 pH 值和交联时间，可以获得具有强凝胶基质的珠粒。结果表明，葡聚糖/吡罗昔康珠粒具有较高的包封效率、非常窄的粒径分布和高的球形度。包衣珠粒保持了未包衣颗粒的形状和较窄的粒径分布。此外，所制备的 Zn(2+)-果胶酸盐珠粒的强度允许减少 Eudragit 包衣的厚度。负载吡罗昔康的多颗粒系统在肠道液中表现出有趣的延长药物释放。因此，此类平台可用于治疗炎症性肠病。
