Render Diane, Samuel Temesgen, King Howard, Vig Madan, Jeelani Shaik, Babu Ramapuram Jayachandra, Rangari Vijaya
Department Materials Science and Engineering, Tuskegee University, Tuskegee, AL 36088, USA.
Department of Pathobiology, Tuskegee University, Tuskegee, AL 36088, USA.
J Nanomater. 2016;2016. doi: 10.1155/2016/3170248.
Oral drug delivery systems provide the most convenient, noninvasive, readily acceptable alternatives to parenteral systems. In the current work, eggshell-derived calcium carbonate (CaCO) nanoparticles were used to develop enteric drug delivery system in the form of tablets. CaCO nanoparticles were manufactured using top-down ball-milling method and characterized by X-ray diffractometry (XRD) and transmission electron microscopy (TEM) and loaded with 5-fluorouracil as a model drug. Tablets with varying CaCO core and binder compositions were fabricated and coated with Eudragit S100 or Eudragit L100. Suitability for enteric delivery of the tablets was tested by oral administration to rabbits and radiography. Radiograph images showed that the tablet remained in the stomach of the rabbit for up to 3 hours. Further modifications of these biomaterial-derived nanoparticles and the coatings will enable manufacturing of stable formulations for slow or controlled release of pharmaceuticals for enteric delivery.
口服给药系统为肠胃外给药系统提供了最方便、无创且易于接受的替代方案。在当前的工作中，蛋壳衍生的碳酸钙（CaCO）纳米颗粒被用于开发片剂形式的肠溶药物递送系统。碳酸钙纳米颗粒采用自上而下的球磨法制造，并通过X射线衍射（XRD）和透射电子显微镜（TEM）进行表征，同时负载5-氟尿嘧啶作为模型药物。制备了具有不同碳酸钙核心和粘合剂组成的片剂，并用尤特奇S100或尤特奇L100进行包衣。通过给兔子口服给药和X射线照相测试了片剂用于肠溶递送的适用性。X射线照片显示该片剂在兔子胃中停留长达3小时。对这些生物材料衍生的纳米颗粒和包衣进行进一步修饰将能够制造出用于肠溶递送药物的缓释或控释稳定制剂。
