Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
Carbohydr Polym. 2013 Jan 30;92(1):719-25. doi: 10.1016/j.carbpol.2012.09.036. Epub 2012 Sep 29.
Methoxy poly (ethylene glycol) grafted carboxymethyl chitosan (mPEG-g-CMC) and alginate were chosen as the constituents of hydrogel beads for the construction of an interpenetrating polymeric network matrix. A contrast study between the mPEG-g-CMC hydrogel and mPEG physically mixed with CMC hydrogel was carried out. Bovine serum albumin (BSA) as a model for a protein drug was encapsulated in the hydrogel network, and the drug release properties were studied. The hydrogels prepared by these two methods maintained good pH sensitivity; the loading capacity of the mPEG-g-CMC/alginate hydrogel was enhanced in comparison with that of the hydrogel prepared by physically mixing mPEG. The burst release of the protein was slightly decreased at pH 1.2, while the release at pH 7.4 was improved, suggesting that the mPEG-g-CMC/alginate pH-sensitive hydrogel will be promising for site-specific protein drug delivery in the intestine.
甲氧基聚乙二醇接枝羧甲基壳聚糖（mPEG-g-CMC）和海藻酸钠被选为水凝胶珠的组成部分，用于构建互穿聚合物网络基质。对 mPEG-g-CMC 水凝胶与 mPEG 与 CMC 物理混合的水凝胶进行了对比研究。牛血清白蛋白（BSA）作为一种蛋白质药物模型被包封在水凝胶网络中，并研究了药物释放性质。这两种方法制备的水凝胶均保持良好的 pH 敏感性；与通过物理混合 mPEG 制备的水凝胶相比，mPEG-g-CMC/海藻酸钠水凝胶的载药量得到了提高。在 pH 1.2 时，蛋白质的突释略有减少，而在 pH 7.4 时释放得到改善，这表明 mPEG-g-CMC/海藻酸钠 pH 敏感水凝胶有望在肠道中实现蛋白质药物的靶向递送。
