• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于甲硝唑控释的双交联海藻酸钠/壳聚糖基水凝胶的研制及其抗菌活性

Development of double crosslinked sodium alginate/chitosan based hydrogels for controlled release of metronidazole and its antibacterial activity.

作者信息

Feyissa Zerihun, Edossa Gemechu Deressa, Gupta Neeraj Kumar, Negera Defaru

机构信息

Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, P.O. Box 1888, Adama, Ethiopia.

出版信息

Heliyon. 2023 Sep 16;9(9):e20144. doi: 10.1016/j.heliyon.2023.e20144. eCollection 2023 Sep.

DOI:10.1016/j.heliyon.2023.e20144
PMID:37809897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10559936/
Abstract

Double network sodium alginate/chitosan hydrogels were prepared using calcium chloride (CaCl) and glutaraldehyde as the crosslinking agents by the ionotropic interaction method for controlled metronidazole release. The effect of polymer ratios and CaCl amount is investigated by the developing porosity, gel fraction, and extent of swelling in simulated physiological fluids. Interaction between the polymers with the formation of crosslinked structures, good stability, phase nature, and morphology of the hydrogels is revealed by Fourier-transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, and scanning electron microscopy. A sodium alginate/chitosan hydrogel (weight ratio of 75:25) crosslinked with two percent CaCl is chosen for the in-situ loading of 200 mg of metronidazole. The drug release kinetics using different models show that the best-fit Korsmeyer-Peppas model suggests metronidazole release from the matrix follows diffusion and swelling-controlled time-dependent non-Fickian transport related to hydrogel erosion. This composition displays enhanced antimicrobial activity against and .

摘要

采用氯化钙（CaCl）和戊二醛作为交联剂，通过离子相互作用法制备了双网络海藻酸钠/壳聚糖水凝胶，用于甲硝唑的控释。通过测定在模拟生理流体中的孔隙率、凝胶分数和溶胀程度，研究了聚合物比例和氯化钙用量的影响。利用傅里叶变换红外光谱、热重分析、X射线衍射和扫描电子显微镜揭示了聚合物之间形成交联结构、良好稳定性、相性质和水凝胶形态的相互作用。选择与2%氯化钙交联的海藻酸钠/壳聚糖水凝胶（重量比75:25）用于原位负载200mg甲硝唑。使用不同模型的药物释放动力学表明，最佳拟合的Korsmeyer-Peppas模型表明甲硝唑从基质中的释放遵循与水凝胶侵蚀相关的扩散和溶胀控制的时间依赖性非菲克传输。该组合物对……显示出增强的抗菌活性。 （原文中“against and.”部分信息缺失，无法完整准确翻译）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/59199f9b8330/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/32232895c0ef/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/3b82bf3f6b0c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/cbff566573c1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/d5f1e986092d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/70e2e3e7442d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/eefaa8f20d4c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/bc903da9ec50/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/bdea9e38f98f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/b67322c18c5c/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/3417e58a6cc9/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/84247fcf7c99/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/094a55394ea5/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/59199f9b8330/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/32232895c0ef/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/3b82bf3f6b0c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/cbff566573c1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/d5f1e986092d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/70e2e3e7442d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/eefaa8f20d4c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/bc903da9ec50/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/bdea9e38f98f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/b67322c18c5c/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/3417e58a6cc9/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/84247fcf7c99/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/094a55394ea5/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/10559936/59199f9b8330/gr12.jpg

相似文献

1
Development of double crosslinked sodium alginate/chitosan based hydrogels for controlled release of metronidazole and its antibacterial activity.用于甲硝唑控释的双交联海藻酸钠/壳聚糖基水凝胶的研制及其抗菌活性
Heliyon. 2023 Sep 16;9(9):e20144. doi: 10.1016/j.heliyon.2023.e20144. eCollection 2023 Sep.
2
Preparation and characterization of hybrid pH-sensitive hydrogels of chitosan-co-acrylic acid for controlled release of verapamil.壳聚糖-丙烯酸共混 pH 敏感水凝胶的制备及表征及其对维拉帕米的控制释放。
J Mater Sci Mater Med. 2010 Oct;21(10):2805-16. doi: 10.1007/s10856-010-4134-1. Epub 2010 Aug 5.
3
Hydrogels based on interpenetrating network of chitosan and polyvinyl pyrrolidone for pH-sensitive delivery of repaglinide.基于壳聚糖和聚乙烯吡咯烷酮互穿网络的水凝胶用于瑞格列奈的pH敏感递送。
Curr Drug Discov Technol. 2011 Jun;8(2):126-35. doi: 10.2174/157016311795563848.
4
Kinetics and controlled release of lidocaine from novel carrageenan and alginate-based blend hydrogels.新型卡拉胶和海藻酸钠基共混水凝胶中利多卡因的动力学和控制释放。
Int J Biol Macromol. 2020 Mar 15;147:67-78. doi: 10.1016/j.ijbiomac.2020.01.073. Epub 2020 Jan 8.
5
Oral delivery of insulin from alginate/chitosan crosslinked by glutaraldehyde.海藻酸钠/壳聚糖经戊二醛交联的胰岛素口服递释系统。
Int J Biol Macromol. 2013 Jul;58:160-8. doi: 10.1016/j.ijbiomac.2013.03.064. Epub 2013 Apr 6.
6
Synthesis of Gallic Acid-Loaded Chitosan-Grafted-2-Acrylamido-2-Methylpropane Sulfonic Acid Hydrogels for Oral Controlled Drug Delivery: In Vitro Biodegradation, Antioxidant, and Antibacterial Effects.用于口服控释给药的载没食子酸壳聚糖接枝2-丙烯酰胺-2-甲基丙烷磺酸水凝胶的合成：体外生物降解、抗氧化及抗菌作用
Gels. 2022 Dec 8;8(12):806. doi: 10.3390/gels8120806.
7
Doxycycline drug delivery using hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide synthesized by electron beam irradiation.利用电子束辐照合成的邻羧甲基壳聚糖与咖啡酸偶联的水凝胶及其与聚丙烯酰胺的复合物递送强力霉素。
Int J Biol Macromol. 2020 Jul 1;154:962-973. doi: 10.1016/j.ijbiomac.2020.03.165. Epub 2020 Mar 20.
8
Loading of Cefixime to pH sensitive chitosan based hydrogel and investigation of controlled release kinetics.将头孢克肟载入 pH 敏感壳聚糖水凝胶及其控释动力学研究。
Int J Biol Macromol. 2020 Jul 15;155:1236-1244. doi: 10.1016/j.ijbiomac.2019.11.091. Epub 2019 Nov 12.
9
Inflammation targeted chitosan-based hydrogel for controlled release of diclofenac sodium.用于双氯芬酸钠控释的炎症靶向壳聚糖基水凝胶
Int J Biol Macromol. 2020 Nov 1;162:175-187. doi: 10.1016/j.ijbiomac.2020.06.133. Epub 2020 Jun 17.
10
Bilayer wound dressing based on sodium alginate incorporated with curcumin-β-cyclodextrin inclusion complex/chitosan hydrogel.基于海藻酸钠与姜黄素-β-环糊精包合物/壳聚糖水凝胶的双层创面敷料。
Int J Biol Macromol. 2020 Dec 1;164:4113-4124. doi: 10.1016/j.ijbiomac.2020.09.013. Epub 2020 Sep 14.

引用本文的文献

1
Effect of Phosphate Phase Incorporation on 3D-Printed Hydrogel Scaffolds: Towards Customizable Bone Graft Materials.磷酸相掺入对3D打印水凝胶支架的影响：迈向可定制骨移植材料
Gels. 2025 Aug 20;11(8):665. doi: 10.3390/gels11080665.
2
Methylene blue removal using alginate-PVA- biocomposite: Kinetics and biodegradation studies.使用藻酸盐-聚乙烯醇生物复合材料去除亚甲蓝：动力学和生物降解研究。
Biotechnol Rep (Amst). 2025 Jul 17;47:e00906. doi: 10.1016/j.btre.2025.e00906. eCollection 2025 Sep.
3
Silane-crosslinked graphene oxide reinforced chitosan/sodium alginate hydrogel for controlled release of insulin.

本文引用的文献

1
-carboxymethyl chitosan/sodium alginate composite hydrogel loading plasmid DNA as a promising gene activated matrix for in-situ burn wound treatment.羧甲基壳聚糖/海藻酸钠复合水凝胶负载质粒DNA作为一种有前景的基因激活基质用于原位烧伤创面治疗。
Bioact Mater. 2021 Dec 20;15:330-342. doi: 10.1016/j.bioactmat.2021.12.012. eCollection 2022 Sep.
2
Metronidazole Based Floating Bioadhesive Drug Delivery System for Potential Eradication of : Preparation and In Vitro Characterization.基于甲硝唑的漂浮型生物黏附药物递送系统用于潜在根除：制备与体外表征
Polymers (Basel). 2022 Jan 27;14(3):519. doi: 10.3390/polym14030519.
3
Preparation, Characterization, and Release Behavior of Doxorubicin hydrochloride from Dual Cross-Linked Chitosan/Alginate Hydrogel Beads.
用于胰岛素控释的硅烷交联氧化石墨烯增强壳聚糖/海藻酸钠水凝胶
RSC Adv. 2025 Jun 12;15(25):19983-20005. doi: 10.1039/d5ra02008e. eCollection 2025 Jun 10.
4
Biogenic silver nanoparticles incorporated hydrogel beads for anticancer and antibacterial activities.载银生物基纳米粒子水凝胶珠的抗肿瘤和抗菌活性。
Sci Rep. 2024 Nov 8;14(1):27269. doi: 10.1038/s41598-024-79003-z.
5
Preparation and Properties of Crosslinked Quaternized Chitosan-Based Hydrogel Films Ionically Bonded with Acetylsalicylic Acid for Biomedical Materials.载阿司匹林的交联季铵化壳聚糖基水凝胶膜的制备及性能研究。
Mar Drugs. 2024 Sep 30;22(10):450. doi: 10.3390/md22100450.
6
Antibacterial and Anticorrosive Hydrogel Coating Based on Complementary Functions of Sodium Alginate and g-CN.基于海藻酸钠和 g-CN 互补功能的抗菌抗腐蚀水凝胶涂层
Molecules. 2024 Sep 4;29(17):4192. doi: 10.3390/molecules29174192.
7
Synthesis, characterization, and biological evaluation of novel cinnamic acid derivatives: cinnamoyl-metronidazole ester and cinnamoyl-memantine amide.新型肉桂酸衍生物：肉桂酰甲硝唑酯和肉桂酰美金刚胺的合成、表征及生物学评价
Heliyon. 2024 Apr 21;10(9):e29851. doi: 10.1016/j.heliyon.2024.e29851. eCollection 2024 May 15.
8
Alginate and Chitosan-Based Hydrogel Enhance Antibacterial Agent Activity on Topical Application.基于藻酸盐和壳聚糖的水凝胶增强局部应用抗菌剂的活性。
Infect Drug Resist. 2024 Mar 1;17:791-805. doi: 10.2147/IDR.S456403. eCollection 2024.
9
Development of a Near-Zero-Waste Valorization Concept for Waste NdFeB Magnets: Production of Antimicrobial Fe Alginate Beads via Adsorption and Recovery of High-Purity Rare-Earth Elements.废钕铁硼磁体近零废物增值概念的开发：通过吸附和回收高纯度稀土元素生产抗菌铁藻酸盐珠。
ACS Omega. 2024 Feb 2;9(6):6442-6454. doi: 10.1021/acsomega.3c06178. eCollection 2024 Feb 13.
盐酸多柔比星从双交联壳聚糖/海藻酸盐水凝胶珠粒中的制备、表征及释放行为
ACS Appl Bio Mater. 2020 May 18;3(5):3057-3065. doi: 10.1021/acsabm.9b01119. Epub 2020 May 5.
4
Fabrication of chitosan-alginate nanospheres for controlled release of cartap hydrochloride.壳聚糖-海藻酸钠纳米球的制备及其对杀螟丹盐酸盐的控制释放。
Nanotechnology. 2021 Oct 22;33(2). doi: 10.1088/1361-6528/ac2d4c.
5
Enhanced physical and antimicrobial properties of alginate/chitosan composite aerogels based on electrostatic interactions and noncovalent crosslinking.基于静电相互作用和非共价交联的藻酸盐/壳聚糖复合气凝胶的增强物理和抗菌性能。
Carbohydr Polym. 2021 Aug 15;266:118102. doi: 10.1016/j.carbpol.2021.118102. Epub 2021 Apr 24.
6
Tunable porosity of covalently crosslinked alginate-based hydrogels and its significance in drug release behavior.可调节交联海藻酸钠水凝胶的孔隙率及其在药物释放行为中的意义。
Carbohydr Polym. 2021 May 15;260:117779. doi: 10.1016/j.carbpol.2021.117779. Epub 2021 Feb 10.
7
Self-assembled guanosine-hydrogels for drug-delivery application: Structural and mechanical characterization, methylene blue loading and controlled release.用于药物递送应用的自组装鸟苷水凝胶：结构与力学表征、亚甲蓝负载及控释
Mater Sci Eng C Mater Biol Appl. 2021 Feb;121:111834. doi: 10.1016/j.msec.2020.111834. Epub 2020 Dec 30.
8
(Macro)molecular self-assembly for hydrogel drug delivery.用于水凝胶药物输送的（宏观）分子自组装。
Adv Drug Deliv Rev. 2021 May;172:275-295. doi: 10.1016/j.addr.2021.01.006. Epub 2021 Jan 12.
9
Topical delivery of clobetasol propionate loaded nanosponge hydrogel for effective treatment of psoriasis: Formulation, physicochemical characterization, antipsoriatic potential and biochemical estimation.负载丙酸氯倍他索的纳米海绵水凝胶局部给药有效治疗银屑病：制剂、理化特性、抗银屑病潜力及生化评估
Mater Sci Eng C Mater Biol Appl. 2021 Feb;119:111605. doi: 10.1016/j.msec.2020.111605. Epub 2020 Oct 9.
10
One Step e-Beam Radiation Cross-Linking of Quaternary Hydrogels Dressings Based on Chitosan-Poly(Vinyl-Pyrrolidone)-Poly(Ethylene Glycol)-Poly(Acrylic Acid).基于壳聚糖-聚（乙烯基吡咯烷酮）-聚乙二醇-聚丙烯酸的一步电子束辐射交联季铵盐水凝胶敷料。
Int J Mol Sci. 2020 Dec 3;21(23):9236. doi: 10.3390/ijms21239236.