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儿童深板层角膜移植术。

Deep anterior lamellar keratoplasty in children.

机构信息

L.V. Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India.

出版信息

Am J Ophthalmol. 2013 Mar;155(3):570-574.e1. doi: 10.1016/j.ajo.2012.09.029. Epub 2012 Dec 4.

Abstract

PURPOSE

To evaluate the outcomes of deep anterior lamellar keratoplasty (DALK) in children.

DESIGN

Retrospective interventional case series.

METHODS

setting: Institutional, L.V. Prasad Eye Institute, a tertiary care center in south India. study population and intervention: All children less than 16 years of age undergoing DALK from January 2003 to January 2011. main outcome measure: Visual outcome and complications.

RESULTS

Twenty-six eyes of 26 children (13 male and 13 female) with a mean age of 7.82 ± 4.64 years underwent DALK for keratoconus (8), microbial keratitis (6), corneal scar (6), corneal keloid (3), chemical injury with limbal stem cell deficiency (2), and dermoid (1). Big bubble was achieved in 5 eyes, while manual dissection was done in 21. Follow-up ranged from 1 week to 7.3 years. Seventeen patients with a minimal follow-up of 6 months were evaluated for visual outcomes. Final vision varied from counting fingers to 20/20 (mean sphere 2.32 diopters, mean cylinder -2.5 diopters). Complications encountered were suture-related graft infiltrate (3), graft dehiscence (3), and Descemet membrane detachment (2).

CONCLUSIONS

DALK is a feasible option in children with stromal corneal pathology. It offers advantages in the form of lower risk of graft rejection. However, the risk of complications such as suture-related infections and graft dehiscence persists even in these cases.

摘要

目的

评估深层板层角膜移植术(DALK)在儿童中的疗效。

设计

回顾性干预性病例系列研究。

方法

研究地点:印度南部的 L.V. 普拉沙德眼科研究所,一家三级保健中心。研究人群和干预措施:2003 年 1 月至 2011 年 1 月期间,所有小于 16 岁行 DALK 的儿童。主要观察指标:视力结果和并发症。

结果

26 例 26 眼(男 13 例,女 13 例)儿童行 DALK,平均年龄 7.82±4.64 岁,病因包括圆锥角膜(8 眼)、微生物性角膜炎(6 眼)、角膜瘢痕(6 眼)、角膜胼胝(3 眼)、化学伤伴角膜缘干细胞缺乏(2 眼)和皮样瘤(1 眼)。5 眼形成大泡,21 眼行手动分离。随访时间为 1 周至 7.3 年。17 例至少随访 6 个月的患者评估了视力结果。最终视力从指数到 20/20(平均球镜 2.32 屈光度,平均柱镜-2.5 屈光度)。发生的并发症包括缝线相关移植物浸润(3 眼)、移植物裂开(3 眼)和后弹力层脱离(2 眼)。

结论

DALK 是治疗儿童基质性角膜病变的可行方法,具有较低的移植物排斥风险优势。然而,即使在这些病例中,缝线相关感染和移植物裂开等并发症的风险仍然存在。

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