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角膜移植术：儿童是否错过了板层革命——2023 年鲍曼俱乐部，大卫·L·伊斯特讲座。

Keratoplasty: are children missing out on the lamellar revolution-the 2023 Bowman Club, David L. Easty Lecture.

机构信息

Singapore National Eye Centre, Singapore.

Singapore National Eye Centre, Singapore

出版信息

BMJ Open Ophthalmol. 2024 Oct 24;9(1):e001804. doi: 10.1136/bmjophth-2024-001804.

DOI:10.1136/bmjophth-2024-001804
PMID:39455068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11529741/
Abstract

There has been a growing interest in lamellar keratoplasty over penetrating keratoplasty in the treatment of cornea diseases. Children, in particular, may benefit from lamellar keratoplasty due to faster visual recovery, better outcomes, fewer eye drops and earlier amblyopia treatment. This review aims to examine the trends, surgical techniques and outcomes in paediatric lamellar keratoplasty. Additionally, alternative treatment modalities to keratoplasty such as selective endothelium removal in Peters anomaly and ophthalmic non-steroidal anti-inflammatory drugs eyedrops in congenital hereditary endothelial dystrophy are also discussed.

摘要

近年来，人们对板层角膜移植术治疗角膜疾病的兴趣日益浓厚，超过了穿透性角膜移植术。由于视觉恢复更快、效果更好、滴眼次数更少以及更早进行弱视治疗，儿童尤其可能受益于板层角膜移植术。本综述旨在探讨儿童板层角膜移植术的趋势、手术技术和结果。此外，还讨论了其他替代角膜移植术的治疗方法，如 Peters 异常的选择性内皮层切除术和先天性遗传性内皮营养不良的眼科非甾体抗炎药滴眼剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856c/11529741/45997bfa2f2e/bmjophth-9-1-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856c/11529741/cdd6462e0d1c/bmjophth-9-1-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856c/11529741/89ef313964b4/bmjophth-9-1-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856c/11529741/9a63afcab598/bmjophth-9-1-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856c/11529741/68eda0460206/bmjophth-9-1-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856c/11529741/45997bfa2f2e/bmjophth-9-1-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856c/11529741/cdd6462e0d1c/bmjophth-9-1-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856c/11529741/89ef313964b4/bmjophth-9-1-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856c/11529741/9a63afcab598/bmjophth-9-1-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856c/11529741/68eda0460206/bmjophth-9-1-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/856c/11529741/45997bfa2f2e/bmjophth-9-1-g005.jpg

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1
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本文引用的文献

1
Updates on congenital hereditary endothelial dystrophy.先天性遗传性内皮营养不良的最新进展。
Taiwan J Ophthalmol. 2023 Nov 28;13(4):405-416. doi: 10.4103/tjo.TJO-D-23-00135. eCollection 2023 Oct-Dec.
2
Selective Endothelialectomy in Peters Anomaly: A Novel Surgical Technique and Its Clinical Outcomes in Children.选择性血管内皮切除术治疗彼得斯异常：一种新的手术技术及其在儿童中的临床疗效。
Cornea. 2022 Dec 1;41(12):1477-1486. doi: 10.1097/ICO.0000000000003134. Epub 2022 Oct 17.
3
Selective endothelial removal: A case series of a phase I/II surgical trial with long-term follow up.
选择性内皮细胞清除：一项具有长期随访的I/II期外科试验的病例系列研究。
Front Med (Lausanne). 2022 Jul 29;9:901187. doi: 10.3389/fmed.2022.901187. eCollection 2022.
4
Altered gene expression in slc4a11 mouse cornea highlights SLC4A11 roles.SLC4A11 基因在 slc4a11 小鼠角膜中的改变表达凸显了 SLC4A11 的作用。
Sci Rep. 2021 Oct 22;11(1):20885. doi: 10.1038/s41598-021-98921-w.
5
Descemet Stripping Automated Endothelial Keratoplasty in Pediatric Age Group: A Decade of Our Experience.儿童年龄组的后弹力层剥除自动角膜内皮移植术：我们十年的经验
Cornea. 2021 Dec 1;40(12):1571-1580. doi: 10.1097/ICO.0000000000002811.
6
Phenotypic Spectrum of Peters Anomaly: Implications for Management.皮特异常表型谱：对治疗的启示。
Cornea. 2022 Feb 1;41(2):192-200. doi: 10.1097/ICO.0000000000002768.
7
Pediatric Descemet Membrane Endothelial Keratoplasty.小儿去表皮角膜内皮移植术。
Am J Ophthalmol. 2021 Jul;227:12-17. doi: 10.1016/j.ajo.2021.02.011. Epub 2021 Feb 12.
8
Outcomes of Descemet's membrane endothelial keratoplasty for congenital hereditary endothelial dystrophy.先天性遗传性内皮层营养不良的 Descemet 膜内皮角膜移植术的结果。
J AAPOS. 2020 Dec;24(6):358.e1-358.e6. doi: 10.1016/j.jaapos.2020.07.018. Epub 2020 Nov 27.
9
Bilateral Descemet Membrane Endothelial Keratoplasty in an Infant With Congenital Hereditary Endothelial Dystrophy.先天性遗传性内皮营养不良婴儿的双侧后弹力层内皮角膜移植术
Cornea. 2021 Sep 1;40(9):1201-1203. doi: 10.1097/ICO.0000000000002616.
10
Long-Term Visual Outcomes and Clinical Course of Patients With Peters Anomaly.Peters 异常患者的长期视觉预后和临床病程。
Cornea. 2021 Jul 1;40(7):822-830. doi: 10.1097/ICO.0000000000002577.