IAP 蛋白：细胞迁移和发育的调节剂。

IAP proteins: regulators of cell migration and development.

机构信息

Department of Pathology, The University of Michigan, Ann Arbor, MI 48109, USA.

出版信息

Curr Opin Cell Biol. 2012 Dec;24(6):871-5. doi: 10.1016/j.ceb.2012.11.004. Epub 2012 Dec 5.

DOI:10.1016/j.ceb.2012.11.004

PMID:23219152

Abstract

The cytoprotective properties of vertebrate inhibitor of apoptosis (IAP) proteins have been the subject of much study. These proteins have, however, emerged as key signaling intermediates modulating a variety of cellular functions through their ability to act as E3 ubiquitin ligases. This review will focus on the cell death-independent roles of the IAP proteins, focusing on recent reports indicating that c-IAPs and XIAP are key molecules involved in modulating cell migration and development.

摘要

脊椎动物细胞凋亡抑制剂（IAP）蛋白的细胞保护特性一直是许多研究的主题。然而，这些蛋白质已成为关键的信号转导介体，通过作为 E3 泛素连接酶的能力来调节各种细胞功能。本综述将重点介绍 IAP 蛋白的细胞死亡非依赖性作用，重点介绍最近的报告表明，c-IAP 和 XIAP 是参与调节细胞迁移和发育的关键分子。