Suppr超能文献

玻璃体内注射贝伐单抗治疗初发性近视性脉络膜新生血管:19个月的结果

[Intravitreal injection of bevacizumab for naive myopic choroidal neovascularization: 19-month results].

作者信息

De Bats F, Grange J-D, Denis P, Kodjikian L

机构信息

Service d'ophtalmologie, hôpital de la Croix-Rousse, 103, Grande-Rue de la Croix-Rousse, 69317 Lyon cedex 4, France.

出版信息

J Fr Ophtalmol. 2013 Jan;36(1):12-8. doi: 10.1016/j.jfo.2012.04.017. Epub 2012 Dec 6.

Abstract

PURPOSE

The purpose of this study was to evaluate the efficacy and safety of bevacizumab in the first-line treatment of myopic choroidal neovascularization.

PATIENTS

We report a retrospective study of patients with subfoveal or juxtafoveal choroidal neovascularization associated with pathologic myopia treated with intravitreal injection of bevacizumab in Lyon, France, from January 2009 to June 2010. Best-corrected visual acuity, ocular pressure, fundus examination, optical coherence tomography, and fluorescein angiography were performed for each patient at baseline and monthly. Indications for retreatment were persistent or recurrence of exsudative activity.

RESULTS

The study included eight eyes of eight patients. The mean follow-up time was 19 months. The mean number of intravitreal injections was three at the end of the first year. Six patients maintained or improved their vision. No injection complications or drug-related side effects were noted during the follow-up period.

CONCLUSIONS

In this study, intravitreal injection of bevacizumab seems to be a safe and effective treatment for myopic choroidal neovascularization.

摘要

目的

本研究旨在评估贝伐单抗在近视性脉络膜新生血管一线治疗中的疗效和安全性。

患者

我们报告了一项对2009年1月至2010年6月在法国里昂接受玻璃体内注射贝伐单抗治疗的、伴有病理性近视的黄斑中心凹下或黄斑中心凹旁脉络膜新生血管患者的回顾性研究。在基线和每月对每位患者进行最佳矫正视力、眼压、眼底检查、光学相干断层扫描和荧光素血管造影。再次治疗的指征为渗出性活动持续或复发。

结果

该研究纳入了8例患者的8只眼。平均随访时间为19个月。在第一年末,玻璃体内注射的平均次数为3次。6例患者视力维持或提高。随访期间未观察到注射并发症或药物相关副作用。

结论

在本研究中,玻璃体内注射贝伐单抗似乎是治疗近视性脉络膜新生血管的一种安全有效的方法。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验