De Bats F, Grange J-D, Denis P, Kodjikian L
Service d'ophtalmologie, hôpital de la Croix-Rousse, 103, Grande-Rue de la Croix-Rousse, 69317 Lyon cedex 4, France.
J Fr Ophtalmol. 2013 Jan;36(1):12-8. doi: 10.1016/j.jfo.2012.04.017. Epub 2012 Dec 6.
The purpose of this study was to evaluate the efficacy and safety of bevacizumab in the first-line treatment of myopic choroidal neovascularization.
We report a retrospective study of patients with subfoveal or juxtafoveal choroidal neovascularization associated with pathologic myopia treated with intravitreal injection of bevacizumab in Lyon, France, from January 2009 to June 2010. Best-corrected visual acuity, ocular pressure, fundus examination, optical coherence tomography, and fluorescein angiography were performed for each patient at baseline and monthly. Indications for retreatment were persistent or recurrence of exsudative activity.
The study included eight eyes of eight patients. The mean follow-up time was 19 months. The mean number of intravitreal injections was three at the end of the first year. Six patients maintained or improved their vision. No injection complications or drug-related side effects were noted during the follow-up period.
In this study, intravitreal injection of bevacizumab seems to be a safe and effective treatment for myopic choroidal neovascularization.
本研究旨在评估贝伐单抗在近视性脉络膜新生血管一线治疗中的疗效和安全性。
我们报告了一项对2009年1月至2010年6月在法国里昂接受玻璃体内注射贝伐单抗治疗的、伴有病理性近视的黄斑中心凹下或黄斑中心凹旁脉络膜新生血管患者的回顾性研究。在基线和每月对每位患者进行最佳矫正视力、眼压、眼底检查、光学相干断层扫描和荧光素血管造影。再次治疗的指征为渗出性活动持续或复发。
该研究纳入了8例患者的8只眼。平均随访时间为19个月。在第一年末,玻璃体内注射的平均次数为3次。6例患者视力维持或提高。随访期间未观察到注射并发症或药物相关副作用。
在本研究中,玻璃体内注射贝伐单抗似乎是治疗近视性脉络膜新生血管的一种安全有效的方法。