Department of Microbiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, Republic of Korea.
Cancer Lett. 2013 Apr 28;330(2):190-9. doi: 10.1016/j.canlet.2012.11.045. Epub 2012 Dec 3.
Peptide vaccines are a clinically applicable therapy shown to be effective in tumor control. In this study, Trp2 peptides plus CpG-oligodeoxynucleotide treatment was found to induce Ag-specific IFN-γ and CD8+CTL responses, and antitumor activity against large established melanoma (tumor size, 7mm). A combination of anti-4.1BB antibodies with Trp2 peptides+CpG-oligodeoxynucleotide increased the antitumor cure rate from 0% to 75%. This effect was concomitant with greater induction of Ag-specific CD8+CTLs and their infiltration into the tumor sites, highlighting the importance of combined stimulation of TLR9 and 4.1BB for achieving tumor eradication. These findings may have implications for designing peptide-based therapeutic vaccines for cancer-patients.
肽疫苗是一种临床适用的治疗方法，已被证明在肿瘤控制方面有效。在这项研究中，发现色氨酸 2 肽加 CpG 寡脱氧核苷酸治疗可诱导 Ag 特异性 IFN-γ 和 CD8+CTL 反应，并具有针对大型已建立的黑色素瘤（肿瘤大小 7mm）的抗肿瘤活性。抗 4-1BB 抗体与色氨酸 2 肽+CpG 寡脱氧核苷酸的联合使用将抗肿瘤治愈率从 0%提高到 75%。这种效果伴随着 Ag 特异性 CD8+CTL 的更大诱导及其浸润到肿瘤部位，突出了 TLR9 和 4-1BB 的联合刺激对于实现肿瘤消除的重要性。这些发现可能对为癌症患者设计基于肽的治疗性疫苗具有重要意义。
