Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan.
Mol Cell Endocrinol. 2013 May 22;371(1-2):148-53. doi: 10.1016/j.mce.2012.11.019. Epub 2012 Dec 5.
Steroidogenic Factor 1 (SF-1, Ad4bp, NR5A1) is a nuclear receptor expressed mainly in the adrenals and gonads. It activates the transcription of genes in steroidogenesis, reproduction, and energy metabolism. In addition, it also regulates the growth and differentiation of adrenogonadal primodial cells. SF-1 resides in the nucleus and the centrosome. SF-1 moves dynamically in the nucleus, and SF-1 location and activity are dynamically regulated by post-translational modifications. In the centrosome, SF-1 maintains genomic integrity by controlling centrosome homeostasis. SF-1 prevents centrosome amplification by restricting aberrant activation of centrosomal DNA-PK. Upon SF-1 removal, DNA-PK is activated and centrosomes are amplified. This leads to genomic instability and cell growth defects. These data indicate that SF-1 at both the nucleus and the centrosome contributes to cell growth control, but the mechanisms of SF-1 action in different locations are different.
类固醇生成因子 1（SF-1，Ad4bp，NR5A1）是一种主要在肾上腺和性腺中表达的核受体。它激活类固醇生成、生殖和能量代谢相关基因的转录。此外，它还调节肾上腺性腺原基细胞的生长和分化。SF-1 位于细胞核和中心体中。SF-1 在细胞核中动态移动，SF-1 的位置和活性受翻译后修饰的动态调节。在中心体中，SF-1 通过控制中心体稳态来维持基因组完整性。SF-1 通过限制中心体 DNA-PK 的异常激活来防止中心体扩增。SF-1 去除后，DNA-PK 被激活，中心体扩增。这导致基因组不稳定和细胞生长缺陷。这些数据表明，SF-1 在细胞核和中心体都有助于细胞生长控制，但 SF-1 在不同位置的作用机制不同。
