Rhodes A R, Mihm M C
Department of Dermatology, University of Pittsburgh, School of Medicine, PA 15213.
Arch Dermatol. 1990 Apr;126(4):500-5.
Cutaneous melanoma developed in contiguity with a congenital nevus spilus on the leg of a 79-year-old white woman. The unique features of the nevus spilus in this case were its relatively large size (diameter, 8 cm), irregular gross appearance, lifelong stability until the recent appearance of a tumor nodule, and the presence of intraepidermal melanocytic dysplasia appearing as multifocal elements within darkly pigmented speckles distributed throughout a lightly pigmented background of lentigo simplex. Based on this observation, we suggest that the presence of intraepidermal melanocytic dysplasia in nevus spilus may be a predisposing factor for the development of melanoma. The malignant potential of "dysplastic" nevus spilus requires further study.
一名79岁白人女性腿部的先天性斑痣旁出现了皮肤黑色素瘤。该病例中斑痣的独特特征包括其相对较大的尺寸（直径8厘米）、外观不规则、在近期出现肿瘤结节之前一直保持终生稳定，以及存在表皮内黑素细胞发育异常，表现为在单纯性雀斑样痣的浅色背景中分布的深色斑点内的多灶性成分。基于这一观察结果，我们认为斑痣中表皮内黑素细胞发育异常可能是黑色素瘤发生的一个易感因素。“发育异常性”斑痣的恶性潜能需要进一步研究。
