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12个月以下儿童及婴儿原发性主动脉缩窄的球囊血管成形术:即刻及中期随访

Balloon angioplasty for native aortic coarctation in children and infants younger than 12 months: immediate and medium-term follow-up.

作者信息

Ammar Rasha I

机构信息

Department of Pediatrics, Faculty of Medicine Cairo University, Pediatrics, Cairo, Egypt.

出版信息

J Invasive Cardiol. 2012 Dec;24(12):662-6.

PMID:23220982
Abstract

BACKGROUND

Despite more than 20 years of experience, balloon angioplasty as treatment for native coarctation of the aorta (CoA) during childhood remains controversial.

METHODS AND RESULTS

Fifty-three pediatric patients with discrete native coarctation for whom balloon angioplasty (BA) was performed were included in this study. Patients were divided into 3 groups: group A patients, ≤3 months of age (n = 20); group B patients, between 4-12 months of age (n = 15); and group C patients, between 1 and 12 years (n = 18). Mean age at BA was 0.9 months for group A, 6.5 months for group B, and 7.8 years for group C. The mean body weight was 4.2 kg for group A, 8.6 kg for group B, and 15.3 kg for group C. Successful BA was achieved in 48 of 53 patients (90.6%). Follow-up revealed re-coarctation in 13/53 patients (24.5%); 6 patients with restenosis were referred for surgery, and 7 underwent a second BA procedure. At the end of the study period, BA was effective in 88.7% of patients. The incidence of peripheral vascular complications following BA was higher in group A (17%). Aneurysms were detected in 3/20 (15%) in group A and 2/15 (13.3%) in group B.

CONCLUSIONS

BA is a safe and effective treatment for native aortic coarctation. Due to the risk of aneurysm formation in children, cautious selection of patients, the use of low-profile balloons, and state-of-the-art postoperative care are imperative to improve patient outcomes and decrease the risk of complications.

摘要

背景

尽管有20多年的经验,但球囊血管成形术作为儿童期原发性主动脉缩窄(CoA)的治疗方法仍存在争议。

方法和结果

本研究纳入了53例接受球囊血管成形术(BA)治疗的原发性离散性主动脉缩窄儿科患者。患者分为3组:A组患者,年龄≤3个月(n = 20);B组患者,年龄在4 - 12个月之间(n = 15);C组患者,年龄在1至12岁之间(n = 18)。A组BA时的平均年龄为0.9个月,B组为6.5个月,C组为7.8岁。A组的平均体重为4.2 kg,B组为8.6 kg,C组为15.3 kg。53例患者中有48例(90.6%)成功完成BA。随访发现53例患者中有13例(24.5%)再狭窄;6例再狭窄患者接受了手术治疗,7例接受了第二次BA手术。在研究期末,BA对88.7%的患者有效。A组BA后周围血管并发症的发生率较高(17%)。A组20例中有3例(15%)检测到动脉瘤,B组15例中有2例(13.3%)。

结论

BA是原发性主动脉缩窄的一种安全有效的治疗方法。由于儿童有形成动脉瘤的风险,谨慎选择患者、使用低轮廓球囊以及采用先进的术后护理对于改善患者预后和降低并发症风险至关重要。

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