Schwartz R W, Qing-Fu H, Logan N M, Richardson D R, Hyde G L
Department of Surgery, University of Kentucky Chandler Medical Center, Lexington.
Arch Surg. 1990 Apr;125(4):485-8. doi: 10.1001/archsurg.1990.01410160071015.
The cutaneous vascular response to gravity load is abnormal in atherosclerosis. In this study we compared the macrocirculatory and microcirculatory response to ischemia in atherosclerotic smokers, nonatherosclerotic smokers, and healthy nonsmokers. Using videodensitometry, the capillary blood velocity of hallux nail fold capillaries was measured at rest and following 1 minute of ankle cuff occlusion. Blood-flow velocity of the dorsal metatarsal artery was measured by ultrasound Doppler. Resting dorsal metatarsal artery velocity and capillary blood velocity of atherosclerotic subjects were lower than those of nonatherosclerotic smokers and nonsmokers. The dorsal metatarsal artery velocity and capillary blood velocity increased in each group following occlusion. Peak postocclusion dorsal metatarsal artery velocity was lower in the atherosclerotic subjects, but peak capillary blood velocity was not significantly different among groups. Atherosclerosis does not alter the mechanisms of reactive hyperemia in either the macrocirculation or the microcirculation. The magnitude of hyperemia is diminished at the macrocirculatory level.
在动脉粥样硬化中，皮肤血管对重力负荷的反应是异常的。在本研究中，我们比较了动脉粥样硬化吸烟者、非动脉粥样硬化吸烟者和健康非吸烟者对缺血的大循环和微循环反应。使用视频密度测定法，在静息状态下以及踝部袖带阻断1分钟后，测量拇趾甲襞毛细血管的毛细血管血流速度。通过超声多普勒测量跖背动脉的血流速度。动脉粥样硬化受试者的静息跖背动脉速度和毛细血管血流速度低于非动脉粥样硬化吸烟者和非吸烟者。阻断后，每组的跖背动脉速度和毛细血管血流速度均增加。动脉粥样硬化受试者阻断后跖背动脉速度峰值较低，但各组间毛细血管血流速度峰值无显著差异。动脉粥样硬化不会改变大循环或微循环中反应性充血的机制。在大循环水平，充血程度降低。
