Wilkie F L, Eisdorfer C, Morgan R, Loewenstein D A, Szapocznik J
Department of Psychiatry, University of Miami, School of Medicine, FL 33136.
Arch Neurol. 1990 Apr;47(4):433-40. doi: 10.1001/archneur.1990.00530040085022.
Relatively little is known about cognitive changes in early human immunodeficiency virus (HIV) infection. This study examined cognitive functioning in 46 HIV-positive gay men relative to an age and education equivalent group of 13 HIV-negative gay men. The HIV-positive men were asymptomatic except for lymphadenopathy or T4 counts less than 700. The cognitive battery measured language, memory, visuospatial, information processing speeds, reasoning, attention, and psychomotor processes. The HIV-positive group was significantly slower in processing information and performed significantly less well than the HIV-negative group on certain verbal memory measures. Deviations of 1 as well as 2 SDs from the norm/control group mean on four or more tests were observed in 43% and 22% of the HIV-positive subjects, respectively, compared with 8% and none of the HIV-negative subjects, respectively. The results suggest that cognitive inefficiency occurs in a subsample of individuals during early HIV infection.
对于人类免疫缺陷病毒（HIV）早期感染时的认知变化，我们所知相对较少。本研究对46名HIV阳性男同性恋者的认知功能进行了检测，并与13名年龄和教育程度相当的HIV阴性男同性恋者组成的对照组进行了比较。这些HIV阳性男性除了有淋巴结病或T4细胞计数低于700外，并无症状。认知测试组测量了语言、记忆、视觉空间、信息处理速度、推理、注意力和心理运动过程。在某些言语记忆测试中，HIV阳性组的信息处理速度明显较慢，表现也明显不如HIV阴性组。分别有43%和22%的HIV阳性受试者在四项或更多测试中偏离正常/对照组均值1个标准差及2个标准差，而HIV阴性受试者的这一比例分别为8%和0%。结果表明，在HIV早期感染阶段，部分个体存在认知效率低下的情况。
