TRPV1 拮抗剂治疗小鼠心肌肥厚和心力衰竭的成功。
Successful TRPV1 antagonist treatment for cardiac hypertrophy and heart failure in mice.
机构信息
Laboratory of Experimental Medicine, Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
出版信息
Channels (Austin). 2013 Jan 1;7(1):17-22. doi: 10.4161/chan.23006. Epub 2012 Dec 6.
Abstract
Heart failure is becoming a global epidemic. It exerts a staggering toll on quality of life, and substantial medical and economic impact. In a pre-clinical model of cardiac hypertrophy and heart failure, we were able to overcome loss of heart function by administering the TRPV1 antagonist BCTC (4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide). The results presented here identify TRPV1 antagonists as new treatment options for cardiac hypertrophy and heart failure.
摘要
心力衰竭正成为一种全球性流行病。它对生活质量造成了巨大影响，还带来了巨大的医疗和经济负担。在心脏肥大和心力衰竭的临床前模型中，我们通过给予 TRPV1 拮抗剂 BCTC（4-(3-氯-2-吡啶基)-N-[4-(1,1-二甲基乙基)苯基]-1-哌嗪甲酰胺）来克服心脏功能的丧失。这里呈现的结果将 TRPV1 拮抗剂确定为心脏肥大和心力衰竭的新治疗选择。
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