Miller Michael, Koch Sheryl E, Veteto Adam, Domeier Timothy, Rubinstein Jack
Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, KY, United States.
Department of Internal Medicine, Division of Cardiovascular Health and Disease, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH, United States.
Front Physiol. 2021 Oct 15;12:734113. doi: 10.3389/fphys.2021.734113. eCollection 2021.
The transient receptor potential (TRP) channels have been described in almost every mammalian cell type. Several members of the Vanilloid (TRPV) subtype have been found to play important roles in modulating cardiac structure and function through Ca handling in response to systemic and local mechanobiological cues. In this review, we will consider the most studied TRPV channels in the cardiovascular field; transient receptor potential vanilloid 1 as a modulator of cardiac hypertrophy; transient receptor potential vanilloid 2 as a structural and functional protein; transient receptor potential vanilloid 3 in the development of hypertrophy and myocardial fibrosis; and transient receptor potential vanilloid 4 in its roles modulating the fibrotic and functional responses of the heart to pressure overload. Lastly, we will also review the potential overlapping roles of these channels with other TRP proteins as well as the advances in translational and clinical arenas associated with TRPV channels.
瞬时受体电位（TRP）通道几乎在每种哺乳动物细胞类型中都有描述。已发现香草酸亚型（TRPV）的几个成员在响应全身和局部机械生物学信号时，通过钙处理在调节心脏结构和功能方面发挥重要作用。在这篇综述中，我们将探讨心血管领域研究最多的TRPV通道；瞬时受体电位香草酸受体1作为心脏肥大的调节剂；瞬时受体电位香草酸受体2作为一种结构和功能蛋白；瞬时受体电位香草酸受体3在肥大和心肌纤维化发展中的作用；以及瞬时受体电位香草酸受体4在调节心脏对压力过载的纤维化和功能反应中的作用。最后，我们还将综述这些通道与其他TRP蛋白潜在的重叠作用，以及与TRPV通道相关的转化和临床领域的进展。
