Flammer K, Aucoin D P, Whitt D A, Styles D K
Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Avian Dis. 1990 Jan-Mar;34(1):228-34.
To determine the potential use of parenteral therapy in the treatment of chlamydiosis in psittacine birds, the disposition and toxicity of a long-acting oxytetracycline (OTC) was evaluated in Goffin's cockatoos. Following intramuscular and subcutaneous administration of 50 to 100 mg/kg body weight, plasma OTC concentrations of 7 to 15 micrograms/ml were obtained 3 hr following injection and declined with a terminal half-life between 8.9 to 14.7 hr. Plasma concentrations in excess of 1.0 microgram/ml were maintained for 48 to 68 hr. Multiple-dose treatment of 100 mg/kg subcutaneously every 3 days for 30 days caused focal necrosis and scabs at the injection site but no other clinical or serological evidence of adverse effects. Long-term treatment did not result in accumulation or alteration in the disposition of OTC. Based on this study, a dosage regimen of 50 to 100 mg/kg of OTC subcutaneously every 2-3 days would safely maintain plasma concentrations in excess of 1.0 microgram/ml and could potentially be used as an alternative to medicated feeds or daily oral dosing regimens for the treatment of chlamydiosis in psittacine birds.
为了确定肠胃外给药疗法在治疗鹦鹉衣原体病中的潜在用途，在戈氏凤头鹦鹉中评估了长效土霉素（OTC）的处置情况和毒性。肌肉注射和皮下注射50至100毫克/千克体重后，注射后3小时血浆OTC浓度达到7至15微克/毫升，并以8.9至14.7小时的终末半衰期下降。血浆浓度超过1.0微克/毫升维持48至68小时。每3天皮下注射100毫克/千克，连续30天的多剂量治疗在注射部位引起局部坏死和结痂，但没有其他不良反应的临床或血清学证据。长期治疗未导致OTC的蓄积或处置改变。基于这项研究，每2至3天皮下注射50至100毫克/千克OTC的给药方案可安全地维持血浆浓度超过1.0微克/毫升，并有可能作为治疗鹦鹉衣原体病的加药饲料或每日口服给药方案的替代方法。
