Suppr
超能文献

比较两个疟疾流行的哥伦比亚地区无症状疟原虫感染情况。

Comparison of asymptomatic Plasmodium spp. infection in two malaria-endemic Colombian locations.

机构信息

Parasitology Group, National Health Institute, Avenida Calle 26 No 51-20, CAN, Bogotá, Colombia.

出版信息

Trans R Soc Trop Med Hyg. 2013 Feb;107(2):129-36. doi: 10.1093/trstmh/trs021. Epub 2012 Dec 2.

DOI:10.1093/trstmh/trs021

PMID:23222954

Abstract

BACKGROUND

Asymptomatic infection by Plasmodium spp. could help explain the dynamics of malaria transmission in low-transmission regions. We therefore compared the prevalence of asymptomatic infection by Plasmodium spp. in two Colombian locations, Tierralta and Tumaco, with different transmission patterns, different ecological and epidemiological characteristics and potentially different associated factors.

METHOD

Two cross-sectional studies were carried out between September 2006 and November 2007. Infection by Plasmodium spp. was determined using polymerase chain reaction (PCR) and microscopy.

RESULTS

Prevalence of asymptomatic infection at day 0 in Tierralta was 11.3% (95% CI 7.2-16.8) by microscopy and 16.5% (95% CI 11.5-22.9) by PCR, while in Tumaco, values were 2.4% (95% CI 0.7-5.5) and 5.8% (95% CI 2.3-9.2) respectively. General prevalence of asymptomatic plasmodium infection after 28 days of follow-up was 5% (95% CI 3.2-7.7), 6.6% (95% CI 3.8-10.6%) in Tierralta and 3.4% (95% CI 1.5-6.6%) in Tumaco. Plasmodium vivax was predominant in Tierralta, P. falciparum in Tumaco. The main associated factors were male sex (aOR 2.5; 95% CI 1.0-6.7) and two to five previous malaria episodes (aOR 3.0; 95% CI 1.0-9.4). PCR detected 61% more infections than microscopy.

CONCLUSION

Measurement of the prevalence of asymptomatic Plasmodium spp. infection is suggested as part of the epidemiologic evaluation of malaria in low-transmission areas such as Colombia.

摘要

背景

无症状感染疟原虫可能有助于解释低传播地区疟疾传播的动态。因此，我们比较了哥伦比亚两个地理位置（Tierralta 和 Tumaco）的无症状疟原虫感染率，这两个地方的传播模式不同，生态和流行病学特征不同，可能的相关因素也不同。

方法

在 2006 年 9 月至 2007 年 11 月期间进行了两项横断面研究。使用聚合酶链反应（PCR）和显微镜检查来确定疟原虫感染情况。

结果

在 Tierralta，第 0 天通过显微镜检查发现无症状感染的患病率为 11.3%（95%置信区间 7.2-16.8），PCR 检查为 16.5%（95%置信区间 11.5-22.9），而在 Tumaco，相应的值分别为 2.4%（95%置信区间 0.7-5.5）和 5.8%（95%置信区间 2.3-9.2）。在 28 天的随访后，无症状疟原虫总感染率为 5%（95%置信区间 3.2-7.7），在 Tierralta 为 6.6%（95%置信区间 3.8-10.6%），在 Tumaco 为 3.4%（95%置信区间 1.5-6.6%）。在 Tierralta 中，主要是间日疟原虫，在 Tumaco 中，主要是恶性疟原虫。主要的相关因素是男性（优势比 2.5；95%置信区间 1.0-6.7）和 2 至 5 次以前的疟疾发作（优势比 3.0；95%置信区间 1.0-9.4）。PCR 检测到的感染比显微镜检查多 61%。