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PTEN at a glance.
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Post-translational modifications of PTEN and their potential therapeutic implications.
Curr Cancer Drug Targets. 2011 Jun;11(5):536-47. doi: 10.2174/156800911795655930.
3
Regulation of PTEN degradation and NEDD4-1 E3 ligase activity by Numb.
Cell Cycle. 2017 May 19;16(10):957-967. doi: 10.1080/15384101.2017.1310351. Epub 2017 Apr 24.
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Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth.
Genes Dev. 2015 Jan 15;29(2):157-70. doi: 10.1101/gad.251785.114. Epub 2014 Dec 29.
5
Redox-sensitive oxidation and phosphorylation of PTEN contribute to enhanced activation of PI3K/Akt signaling in rostral ventrolateral medulla and neurogenic hypertension in spontaneously hypertensive rats.
Antioxid Redox Signal. 2013 Jan 1;18(1):36-50. doi: 10.1089/ars.2011.4457. Epub 2012 Aug 16.
6
PTEN regulation, a novel function for the p85 subunit of phosphoinositide 3-kinase.
Sci STKE. 2006 Nov 21;2006(362):pe49. doi: 10.1126/stke.3622006pe49.
7
PTEN: a default gate-keeping tumor suppressor with a versatile tail.
Cell Res. 2008 Aug;18(8):807-16. doi: 10.1038/cr.2008.83.
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Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN.
Neoplasia. 2015 Apr;17(4):367-73. doi: 10.1016/j.neo.2015.03.002.
9
Post-translational regulation of PTEN.
Oncogene. 2008 Sep 18;27(41):5454-63. doi: 10.1038/onc.2008.242.
10
Characterization of nuclear PTEN and its post translational modifications.
Methods. 2015 May;77-78:104-11. doi: 10.1016/j.ymeth.2015.01.006. Epub 2015 Jan 20.
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The complexity of phosphatase and tensin homolog hamartoma tumor syndrome: A case report.
SAGE Open Med Case Rep. 2024 Apr 6;12:2050313X241245317. doi: 10.1177/2050313X241245317. eCollection 2024.
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Distinct early role of PTEN regulation during HCMV infection of monocytes.
Proc Natl Acad Sci U S A. 2024 Mar 19;121(12):e2312290121. doi: 10.1073/pnas.2312290121. Epub 2024 Mar 14.
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Expression of microRNAs related to apoptosis in the aqueous humor and lens capsule of patients with glaucoma.
Front Med (Lausanne). 2024 Feb 14;11:1288854. doi: 10.3389/fmed.2024.1288854. eCollection 2024.
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The Role of the PTEN Tumor Suppressor Gene and Its Anti-Angiogenic Activity in Melanoma and Other Cancers.
Molecules. 2024 Feb 4;29(3):721. doi: 10.3390/molecules29030721.
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Nuclear PTEN's Functions in Suppressing Tumorigenesis: Implications for Rare Cancers.
Biomolecules. 2023 Jan 30;13(2):259. doi: 10.3390/biom13020259.
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Nanotechnology-Based Nucleic Acid Vaccines for Treatment of Ovarian Cancer.
Pharm Res. 2023 Jan;40(1):123-144. doi: 10.1007/s11095-022-03434-4. Epub 2022 Nov 14.
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Smurf1 Suppression Enhances Temozolomide Chemosensitivity in Glioblastoma by Facilitating PTEN Nuclear Translocation.
Cells. 2022 Oct 20;11(20):3302. doi: 10.3390/cells11203302.
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The Role of PTEN in Epithelial-Mesenchymal Transition.
Cancers (Basel). 2022 Aug 3;14(15):3786. doi: 10.3390/cancers14153786.
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Identification and Somatic Characterization of the Germline Promoter Variant rs34149102 in a Family with Gastrointestinal and Breast Tumors.
Genes (Basel). 2022 Apr 5;13(4):644. doi: 10.3390/genes13040644.
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Promoting axon regeneration in the central nervous system by increasing PI3-kinase signaling.
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Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia.
J Cell Biol. 2012 Jan 9;196(1):29-36. doi: 10.1083/jcb.201105009. Epub 2012 Jan 2.
2
In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma.
Cell. 2011 Oct 14;147(2):382-95. doi: 10.1016/j.cell.2011.09.032.
3
Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress.
J Biol Chem. 2011 Oct 21;286(42):36631-40. doi: 10.1074/jbc.M110.217620. Epub 2011 Aug 26.
4
Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.
Cancer Cell. 2011 Aug 16;20(2):173-86. doi: 10.1016/j.ccr.2011.07.013.
5
On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN).
Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10349-54. doi: 10.1073/pnas.1103503108. Epub 2011 Jun 6.
6
Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins.
EMBO J. 2011 Jun 3;30(13):2557-68. doi: 10.1038/emboj.2011.178.
7
Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells.
Mol Cell Biol. 2011 Jul;31(13):2756-71. doi: 10.1128/MCB.01323-10. Epub 2011 May 2.
8
WWP2 is an E3 ubiquitin ligase for PTEN.
Nat Cell Biol. 2011 Jun;13(6):728-33. doi: 10.1038/ncb2240. Epub 2011 May 1.
9
Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway.
Leukemia. 2011 Jul;25(7):1064-79. doi: 10.1038/leu.2011.46. Epub 2011 Mar 25.
10
E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression.
Oncogene. 2011 Jun 16;30(24):2753-66. doi: 10.1038/onc.2011.6. Epub 2011 Feb 7.
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