Wang X, Jiang X
Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Oncogene. 2008 Sep 18;27(41):5454-63. doi: 10.1038/onc.2008.242.
PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor regulates a variety of cellular processes including cell proliferation, growth, migration and death. This master regulator itself is also under deliberative regulation. Although the evidence for PTEN regulation and its significance in normal biology and disease is overwhelming, the mechanisms and exact functional consequences of PTEN regulation are far from clear. In this review, we discuss recent advances concerning post-translational regulation of PTEN in general, and in more detail about its regulation by ubiquitination. We also discuss some unsolved questions in the field and how they might be addressed in the future. We propose that the complex regulatory mechanisms of PTEN dictate how this tumor suppressor executes its distinct biological functions.
PTEN（第10号染色体缺失的磷酸酶及张力蛋白同源物）肿瘤抑制因子调控多种细胞过程，包括细胞增殖、生长、迁移和死亡。这个主要调节因子自身也受到精细调控。尽管关于PTEN调控及其在正常生物学和疾病中的意义的证据极为丰富，但PTEN调控的机制及确切功能后果仍远未明确。在本综述中，我们讨论了PTEN翻译后调控的近期进展，更详细地探讨了其泛素化调控。我们还讨论了该领域一些未解决的问题以及未来可能的解决方式。我们提出，PTEN复杂的调控机制决定了这个肿瘤抑制因子如何执行其独特的生物学功能。
