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[A 75-year-old female patient with pleural effusion and gastric metastases of a poorly differentiated carcinoma].

作者信息

Roeb E, Dreyer T, Steiner D, Bräuninger A, Gattenlöhner S

机构信息

Zentrum für Innere Medizin, Schwerpunkt Gastroenterologie, Medizinische Klinik II, Universitätsklinikum Gießen und Marburg (UKGM) und Justus-Liebig-Universität Gießen, Klinikstr. 33, 35385, Gießen.

出版信息

Internist (Berl). 2013 Feb;54(2):242, 244-8. doi: 10.1007/s00108-012-3184-5.

DOI:10.1007/s00108-012-3184-5
PMID:23223952
Abstract

A 75-year-old woman was found to have left-sided pleural effusion and endoscopy revealed the rare entity of adenoid cystic carcinoma metastases in the gastric mucosa. Approximately 20% of patients with this carcinoma suffer from distant metastases. For the initial staging detection of adenoid cystic carcinoma metastasis with positron emission tomography (PET) or PET computed tomography (CT) is recommended. The recurrent t(6;9)(q22-23;p23-24) translocation that results in a fusion of the two transcription factor genes MYB and NFIB is detectable in half of the cases. As in our case molecular pathology can confirm the correct diagnosis and identification of the localization of the primary tumor.

摘要

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本文引用的文献

1
A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry.比较主要和次要涎腺与《监测、流行病学和最终结果》登记处内较少见部位的腺样囊性癌患者的人口统计学、临床特征和生存情况。
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4
Novel chromosomal rearrangements and break points at the t(6;9) in salivary adenoid cystic carcinoma: association with MYB-NFIB chimeric fusion, MYB expression, and clinical outcome.涎腺腺样囊性癌中 t(6;9)的新型染色体重排和断裂点:与 MYB-NFIB 嵌合融合、MYB 表达和临床结果的关联。
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The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma.MYB-NFIB 基因融合——腺样囊性癌和皮肤圆柱瘤之间的新的遗传联系。
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MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation.MYB 表达与易位在腺样囊性癌和其他具有临床病理相关性的唾液腺肿瘤中的研究。
Am J Surg Pathol. 2011 Jan;35(1):92-9. doi: 10.1097/PAS.0b013e3182002777.
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Phase II study of cisplatin and imatinib in advanced salivary adenoid cystic carcinoma.顺铂与伊马替尼治疗晚期涎腺腺样囊性癌的II期研究。
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An update on grading of salivary gland carcinomas.唾液腺癌分级的最新进展。
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FDG PET in detecting primary and recurrent malignant salivary gland tumors.氟代脱氧葡萄糖正电子发射断层扫描在检测原发性和复发性恶性涎腺肿瘤中的应用
Clin Nucl Med. 2007 Apr;32(4):286-91. doi: 10.1097/01.rlu.0000257336.69537.cb.