Department of Physics, Indian Institute of Science, Bangalore 560012, India.
J Biomed Opt. 2012 Oct;17(10):101507. doi: 10.1117/1.JBO.17.10.101507.
We demonstrate quantitative optical property and elastic property imaging from ultrasound assisted optical tomography data. The measurements, which are modulation depth M and phase ϕ of the speckle pattern, are shown to be sensitively dependent on these properties of the object in the insonified focal region of the ultrasound (US) transducer. We demonstrate that Young's modulus (E) can be recovered from the resonance observed in M versus ω (the US frequency) plots and optical absorption (μ(a)) and scattering (μ(s)) coefficients from the measured differential phase changes. All experimental observations are verified also using Monte Carlo simulations.
我们从超声辅助光学层析成像数据中演示了定量光学性质和弹性性质成像。实验结果表明，声（US）换能器照射焦区的物体的这些性质对散斑图案的调制深度 M 和相位 ϕ 非常敏感。我们证明，杨氏模量（E）可以从 M 与 ω（US 频率）的关系图中观察到的共振中恢复，并且可以从测量的差分相位变化中恢复光学吸收（μ(a)）和散射（μ(s)）系数。所有的实验观察结果也都通过蒙特卡罗模拟进行了验证。
