Key Laboratory of Laser Life Science of Ministry of Education of China, South China Normal University, Guangzhou 510631, Guangdong, China.
J Biomed Opt. 2012 Oct;17(10):101513. doi: 10.1117/1.JBO.17.10.101513.
Recently, the capability of optical coherence tomography (OCT) has been demonstrated for noninvasive blood glucose monitoring. In this work, we investigate the administration of chemical agents onto human skin tissue to increase the transparency of the surface of the skin, as a means of improving the capability of OCT imaging for clinically relevant applications. Eight groups of experiments were proposed, in which different optical clearing agents (OCA) were used. The results indicate that, when properly used, some OCAs perform well in promoting the capability of OCT for noninvasive blood glucose monitoring. Among the four kinds of OCA we used, 50% v/v glycerol solute turns out to be the best enhancer. Compared with the results of the experiments in which no OCA was used, when 50% glycerol was applied onto the human skin topically, the correlation coefficient between the OCT signal slope (OCTSS) and blood glucose concentration (BGC) was improved by 7.1% on average, and the lag time between changes in the OCTSS and BGC was cut by 8 min on average. The results of 10 w/v mannitol were also good, but not as pronounced.
最近，光学相干断层扫描（OCT）的功能已被证明可用于非侵入式血糖监测。在这项工作中，我们研究了向人体皮肤组织施用化学试剂以提高皮肤表面透明度的方法，这是改善 OCT 成像能力以用于临床相关应用的一种手段。提出了八组实验，其中使用了不同的光学透明剂（OCA）。结果表明，在适当使用的情况下，某些 OCA 在促进 OCT 进行非侵入式血糖监测方面表现良好。在所使用的四种 OCA 中，50%的甘油溶质表现最佳。与未使用 OCA 的实验结果相比，当将 50%的甘油局部应用于人体皮肤时，OCT 信号斜率（OCTSS）与血糖浓度（BGC）之间的相关系数平均提高了 7.1%，并且 OCTSS 和 BGC 之间变化的滞后时间平均缩短了 8 分钟。10%的甘露醇的结果也很好，但不如甘油明显。
