在猕猴感染猴免疫缺陷病毒早期，循环 IL-21 水平升高。

Circulating IL-21 levels increase during early simian-human immunodeficiency virus infection in macaques.

机构信息

Institute of Laboratory Animal Science, Peking Union Medical College, Chinese Academy of Medical Sciences and Comparative Medical Center, No.5 Panjiayuan Nanli, Chaoyang Dist, 100021, Beijing, People's Republic of China.

出版信息

Arch Virol. 2013 Apr;158(4):853-8. doi: 10.1007/s00705-012-1534-1. Epub 2012 Dec 8.

DOI:10.1007/s00705-012-1534-1

PMID:23224786

Abstract

The cytokine interleukin-21 (IL-21) regulates viral pathogenesis in individuals infected with human and simian immunodeficiency viruses. However, because the time of initial infection with HIV in humans is rarely known, the dynamics of IL-21 production during the first weeks have not been adequately explored. In the present study, we used rhesus macaques to model the first stages of infection. Twenty-two rhesus macaques were infected rectally with simian-human immunodeficiency virus (SHIV)-1157ipd3N4, and for 12 weeks, replication of the virus, the numbers of CD4+ and CD8+ T cells, and the levels of plasma IL-21 were monitored. Our study demonstrated that plasma levels of IL-21 increased during the early phase of SHIV infection when compared with the values observed before inoculation. We conclude that IL-21 has a likely role in the immunopathogenesis of HIV/SIV/SHIV.

摘要

细胞因子白细胞介素-21（IL-21）调节感染人类和猿免疫缺陷病毒个体的病毒发病机制。然而，由于人类感染 HIV 的初始时间很少被知晓，因此在最初几周内 IL-21 产生的动态变化尚未得到充分研究。在本研究中，我们使用恒河猴来模拟感染的早期阶段。22 只恒河猴经直肠感染了猴免疫缺陷病毒-1157ipd3N4，在接下来的 12 周内，监测病毒的复制、CD4+和 CD8+T 细胞的数量以及血浆 IL-21 的水平。我们的研究表明，与接种前观察到的数值相比，在 SHIV 感染的早期阶段，血浆中 IL-21 的水平升高。我们得出结论，IL-21 在 HIV/SIV/SHIV 的免疫发病机制中可能发挥作用。