Department of Neuroscience, Federico II University of Naples, Naples, Italy.
Adv Exp Med Biol. 2013;961:137-45. doi: 10.1007/978-1-4614-4756-6_12.
The ubiquitous sodium-calcium exchanger isoform 1 (NCX1) is a -bidirectional transporter that plays a relevant role under physiological and pathophysiological conditions including brain ischemia by regulating intraneuronal Ca(2+) and Na(+) homeostasis. Although changes in ncx1 protein and transcript expression have been detected during stroke, its transcriptional regulation is still largely unexplored. Here, we reviewed our recent findings on several transcription factors including cAMP response element-binding protein (CREB), nuclear factor kappa B (NF-κB), and hypoxia-inducible factor-1 (HIF-1) in the control of the ncx1 gene expression in neuronal cells.
普遍存在的钠钙交换体 1 型（NCX1）是一种双向转运体，在包括脑缺血在内的生理和病理生理条件下，通过调节细胞内 Ca（2+）和 Na（+）稳态发挥重要作用。尽管在中风期间已经检测到 ncx1 蛋白和转录本表达的变化，但对其转录调控仍知之甚少。在这里，我们回顾了我们最近在几个转录因子（包括 cAMP 反应元件结合蛋白（CREB）、核因子 kappa B（NF-κB）和缺氧诱导因子-1（HIF-1））对神经元细胞中 ncx1 基因表达的控制方面的发现。
