SRC为生物标志物和化疗靶点指明了方向。
SRC points the way to biomarkers and chemotherapeutic targets.
作者信息
Krishnan Harini, Miller W Todd, Goldberg Gary S
机构信息
University of Medicine and Dentistry of New Jersey, Graduate School of Biomedical Sciences, School of Osteopathic Medicine, Stratford, NJ, USA.
出版信息
Genes Cancer. 2012 May;3(5-6):426-35. doi: 10.1177/1947601912458583.
Abstract
The role of Src in tumorigenesis has been extensively studied since the work of Peyton Rous over a hundred years ago. Src is a non-receptor tyrosine kinase that plays key roles in signaling pathways controlling tumor cell growth and migration. Src regulates the activities of numerous molecules to induce cell transformation. However, transformed cells do not always migrate and realize their tumorigenic potential. They can be normalized by surrounding nontransformed cells by a process called contact normalization. Tumor cells need to override contact normalization to become malignant or metastatic. In this review, we discuss the role of Src in cell migration and contact normalization, with emphasis on Cas and Abl pathways. This paradigm illuminates several chemotherapeutic targets and may lead to the identification of new biomarkers and the development of effective anticancer treatments.
摘要
自一百多年前佩顿·劳斯的研究工作以来，Src在肿瘤发生中的作用已得到广泛研究。Src是一种非受体酪氨酸激酶，在控制肿瘤细胞生长和迁移的信号通路中起关键作用。Src调节众多分子的活性以诱导细胞转化。然而，转化细胞并不总是迁移并实现其致瘤潜力。它们可以通过一种称为接触归一化的过程被周围的未转化细胞归一化。肿瘤细胞需要克服接触归一化才能变得恶性或转移。在本综述中，我们讨论Src在细胞迁移和接触归一化中的作用，重点是Cas和Abl途径。这种模式阐明了几个化疗靶点，并可能导致新生物标志物的识别和有效抗癌治疗的开发。
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