Hou Wenmin, Fei Maogui, Qin Xia, Zhu Xuehua, Greshock Joel, Liu Ping, Zhou Yuanfeng, Wang Hui, Ye Bang-Ce, Qin Crystal Ying
Laboratory of Biosystems and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology; ; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences;
Exp Ther Med. 2012 Dec;4(6):999-1004. doi: 10.3892/etm.2012.727. Epub 2012 Sep 27.
Fatty acid synthase (FAS) is the key enzyme regulating de novo biosynthesis of fatty acids. FAS overexpression has been found in many types of tumors and is associated with poor survival. However, the expression of FAS and its relationship with prognosis in Chinese patients with gastric carcinoma are still unknown. Therefore, in this study, we examined the expression of FAS using tissue microarrays and determined its correlation with clinicopathological characteristics and prognosis of gastric carcinoma in Chinese patients. FAS overexpression was graded as S (T/A) <1, ≥1 to <2, ≥2 to <3 or ≥3 in 35 (38.9%), 20 (22.2%), 9 (10%) and 26 (28.9%) patients, respectively. High FAS overexpression [S (T/A) ≥3] was significantly correlated with poor prognosis (log-rank test, P= 0.0078) and with decreased 3-year survival rate (χ(2) test, P=0.0023). FAS overexpression was not significantly associated with other clinicopathological characteristics. In conclusion, our results suggest that FAS expression might be a potential prognostic marker for gastric carcinoma in Chinese patients.
脂肪酸合酶（FAS）是调控脂肪酸从头生物合成的关键酶。FAS过表达在多种肿瘤中均有发现，且与患者预后不良相关。然而，FAS在中国胃癌患者中的表达情况及其与预后的关系仍不清楚。因此，在本研究中，我们利用组织芯片检测了FAS的表达，并确定其与中国胃癌患者临床病理特征及预后的相关性。FAS过表达分别在35例（38.9%）、20例（22.2%）、9例（10%）和26例（28.9%）患者中被分为S（T/A）<1、≥1至<2、≥2至<3或≥3级。高FAS过表达[S（T/A）≥3]与预后不良显著相关（对数秩检验，P = 0.0078），并与3年生存率降低相关（χ²检验，P = 0.0023）。FAS过表达与其他临床病理特征无显著相关性。总之，我们的结果表明，FAS表达可能是中国胃癌患者的一个潜在预后标志物。
