Kang Shin Myung, Baek Ji Yeon, Hwangbo Bin, Kim Hyae-Young, Lee Geon-Kook, Lee Hee Seok
Center for Lung Cancer, National Cancer Center, Goyang, Korea. ; Department of Pulmonary and Critical Care Medicine, Gachon University Gil Hospital, Incheon, Korea.
Tuberc Respir Dis (Seoul). 2012 Mar;72(3):318-22. doi: 10.4046/trd.2012.72.3.318. Epub 2012 Mar 31.
Sarcoidosis is an inflammatory disease involving multiple-organs with an unknown cause. The new onset of sarcoidosis associated with therapeutic agents has been observed in 3 clinical settings; tumor necrosis factor antagonists in autoimmune rheumatologic diseases, interferon alpha with or without ribavirin in patients with chronic hepatitis C or melanoma, and antineoplastic agent-associated sarcoidosis in patients with hematologic malignancies. Here, we report a female patient who developed sarcoidosis after capecitabine treatment as an adjuvant chemotherapy for sigmoid colon cancer. To our knowledge, this is the first report of a capecitabine-induced sarcoidosis.
结节病是一种病因不明的累及多器官的炎症性疾病。在3种临床情况下观察到与治疗药物相关的结节病新发病例：自身免疫性风湿性疾病中使用肿瘤坏死因子拮抗剂、慢性丙型肝炎或黑色素瘤患者使用含或不含利巴韦林的干扰素α，以及血液系统恶性肿瘤患者中与抗肿瘤药物相关的结节病。在此，我们报告一名女性患者，其在接受卡培他滨作为乙状结肠癌辅助化疗后发生了结节病。据我们所知，这是卡培他滨诱发结节病的首例报告。
