Gayet Albéric-Rembrandt, Plaisance Patrick, Bergmann Jean-François, Mouly Stéphane
Emergency Department, Assistance Publique-Hôpitaux de Paris, Lariboisière Hospital, Paris, France.
Clin Med Res. 2010 Dec;8(3-4):163-7. doi: 10.3121/cmr.2010.886. Epub 2010 Sep 17.
Sarcoidosis is a chronic inflammatory multisystem disease of unknown etiology. We report on a woman, aged 57 years, presenting with typical sarcoidosis occurring two months after completion of a six-month course of interferon-α and ribavirin for chronic hepatitis C virus infection. The current observation is interesting with regard to the time elapsed between the occurrence of symptoms and antiviral treatment withdrawal, and spontaneous recovery after ten months of follow-up. Pathophysiological mechanisms involved in the development of antiviral therapy-induced sarcoidosis are discussed.
结节病是一种病因不明的慢性炎症性多系统疾病。我们报告了一名57岁女性,在完成针对慢性丙型肝炎病毒感染的为期6个月的干扰素-α和利巴韦林治疗两个月后出现典型的结节病。就症状出现与停用抗病毒治疗之间的时间间隔以及随访10个月后的自发恢复而言,目前的观察结果很有意思。文中讨论了抗病毒治疗诱导结节病发生所涉及的病理生理机制。