Patsatsi Aikaterini, Kyriakou Aikaterini, Pavlitou-Tsiontsi Aikaterini, Giannakou Anastasia, Sotiriadis Dimitrios
2nd Department of Dermatology and Venereology, Papageorgiou General Hospital, Aristotle University School of Medicine, Thessaloniki, Greece.
Clin Dev Immunol. 2012;2012:854795. doi: 10.1155/2012/854795. Epub 2012 Nov 27.
39 bullous pemphigoid (BP) patients were studied to assess the clinical significance of anti-BP180 and anti-BP230 circulating autoantibodies of BP and correlate their titers with the clinical scores of the BP Disease Area Index (BPDAI) and the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) as well as with the intensity of pruritus measured by the BPDAI pruritus component. All parameters were evaluated by the time of diagnosis (baseline), month 3, and month 6. Titers of anti-BP180 autoantibodies were strongly correlated with BPDAI (r = 0.557, P value < 0.0001) and ABSIS (r = 0.570, P value < 0.0001) values, as well as with BPDAI component for the intensity of pruritus (rho = 0.530, P value = 0.001) at baseline. At month 3, titers of anti-BP180 autoantibodies were strongly correlated with BPDAI (rho = 0.626, P value = 0.000) and ABSIS (rho = 0.625, P value = 0.000) values, as well as with the BPDAI component for the intensity of pruritus (rho = 0.625, P value = 0.000). At month 6, titers of anti-BP180 autoantibodies were strongly correlated with BPDAI (rho = 0.527, P value = 0.001) and ABSIS (rho = 0.526, P value = 0.001) values, as well as with the BPDAI component for the intensity of pruritus (rho = 0.525, P value = 0.001). There was no statistically significant correlation between titers of anti-BP230 autoantibodies and the BPDAI, ABSIS, and BPDAI component for the intensity of pruritus at the same time points.
对39例大疱性类天疱疮（BP）患者进行研究，以评估BP循环自身抗体抗BP180和抗BP230的临床意义，并将其滴度与BP疾病面积指数（BPDAI）和自身免疫性大疱性皮肤病强度评分（ABSIS）的临床评分以及由BPDAI瘙痒成分测量的瘙痒强度相关联。所有参数在诊断时（基线）、第3个月和第6个月进行评估。抗BP180自身抗体滴度在基线时与BPDAI（r = 0.557，P值<0.0001）和ABSIS（r = 0.570，P值<0.0001）值以及与瘙痒强度的BPDAI成分（rho = 0.530，P值 = 0.001）密切相关。在第3个月，抗BP180自身抗体滴度与BPDAI（rho = 0.626，P值 = 0.000）和ABSIS（rho = 0.625，P值 = 0.000）值以及与瘙痒强度的BPDAI成分（rho = 0.625，P值 = 0.000）密切相关。在第6个月，抗BP180自身抗体滴度与BPDAI（rho = 0.527，P值 = 0.001）和ABSIS（rho = 0.526，P值 = 0.001）值以及与瘙痒强度的BPDAI成分（rho = 0.525，P值 = 0.001）密切相关。在相同时间点，抗BP230自身抗体滴度与BPDAI、ABSIS以及瘙痒强度的BPDAI成分之间无统计学显著相关性。
