Islam N, Rahman M M, Aziz M A, Begum F, Yunus A B M
Department of Haematology, National Institute of Cancer Research and Hospital (NICRH), Dhaka.
Bangladesh Med Res Counc Bull. 2012 Aug;38(2):43-6. doi: 10.3329/bmrcb.v38i2.12879.
Cure rates for adult acute lymphoblastic leukaemia (ALL) in developing countries are significantly lower because of problems unique to these countries. Recent studies have reported complete response rates for any induction regimen of more than 90% in adult ALL patients. This study was conducted to evaluate the response rate of induction chemotherapy in adult ALL patients in the Department of Haematology, Bangabandhu Sheikh Mujib Medical University, from January 2007 to December 2008. In this observational study, 35 newly diagnosed ALL patients classified either as L1/L2 according to French-American-British (FAB) classification, aged between 15 to 60 years were assigned for induction therapy with modified MRC UKALL XII/ECOG E2993 protocol. But ultimately 30 patients completed therapy and available for statistical analysis. Among the studied 30 cases 12(40%) patients after phase 1 and overall 24 (80%) patients after phase 2 induction therapy, achieved morphologic complete remission (CR). After phase 2 therapy 6 (20%) patients fell in the group of non responders (NR) as the blast percentage was > or = 5% at the time of bone marrow evaluation. This study shows the response rates in adult ALL with induction therapy slightly below the anticipated response rates of developed countries which may be due to little modification of the original protocol.
由于发展中国家存在一些独特问题，其成人急性淋巴细胞白血病（ALL）的治愈率显著较低。最近的研究报告称，成人ALL患者接受任何诱导方案后的完全缓解率超过90%。本研究旨在评估2007年1月至2008年12月期间，孟加拉国谢赫·穆吉布医学大学血液科成人ALL患者诱导化疗的缓解率。在这项观察性研究中，35例新诊断的ALL患者根据法国-美国-英国（FAB）分类法被归类为L1/L2型，年龄在15至60岁之间，被分配接受改良的MRC UKALL XII/ECOG E2993方案诱导治疗。但最终有30例患者完成治疗并可进行统计分析。在研究的30例病例中，12例（40%）患者在第1阶段后，24例（80%）患者在第2阶段诱导治疗后实现了形态学完全缓解（CR）。在第2阶段治疗后，6例（20%）患者属于无反应者（NR）组，因为在骨髓评估时原始细胞百分比≥5%。本研究表明，成人ALL诱导治疗的缓解率略低于发达国家预期的缓解率，这可能是由于对原始方案的修改较少。
