Roshchina G Ia, Koroleva V I, Davydov V I
Zh Vyssh Nerv Deiat Im I P Pavlova. 2012 Sep-Oct;62(5):610-8.
EEG aftereffects of spreading depression waves were studied in waking rabbits in chronic experiments by spectral coherence analysis. Experiments were divided in two groups: early (from the first to the third-fourth experiments) and late (fifth-tenth experiments). During the early experimental series, unilateral persistent EEG changes consisting in an increase in the delta- and beta-band power with a simultaneous depression of the gamma-band activity were observed in the ipsilateral to SD hemisphere. In addition, interhemispheric coherence between symmetrical cortical points decreased. During the late experimental series, a generalized bilateral increase in the power of the delta and beta activity was demonstrated with a rise in coherence in the beta band. This generalized activity occurred cyclically and was distinct during a long period of time (2-3 hours) after propagation of a single SD wave. Such kind of cyclical activity blocked the propagation of subsequent SD waves in the neocortex of a waking rabbit and decreased the probability of recurrent wave origin up to a complete cessation of wave generation. Thus, a cortical SD wave provoked the appearance of synchronized beta oscillations in the EEG, which in turn actively influenced the properties of recurrent waves.
通过频谱相干分析，在慢性实验中对清醒家兔传播性抑郁波后的脑电图（EEG）后效应进行了研究。实验分为两组：早期（从第一次到第三次或第四次实验）和晚期（第五次到第十次实验）。在早期实验系列中，在与传播性抑郁同侧的半球观察到单侧持续性EEG变化，表现为δ波和β波功率增加，同时γ波活动受到抑制。此外，对称皮质点之间的半球间相干性降低。在晚期实验系列中，δ波和β波活动的功率普遍双侧增加，β波段的相干性上升。这种普遍活动呈周期性出现，在单个传播性抑郁波传播后的很长一段时间（2 - 3小时）内都很明显。这种周期性活动阻止了后续传播性抑郁波在清醒家兔新皮质中的传播，并降低了复发波产生的概率，直至波的产生完全停止。因此，皮质传播性抑郁波引发了脑电图中同步β振荡的出现，而这反过来又积极影响了复发波的特性。
