通过 AuCl3 催化的 1-(吲哚-2-基)-3-炔-1-醇的环化反应合成咔唑。
Carbazoles via AuCl3-catalyzed cyclization of 1-(indol-2-yl)-3-alkyn-1-ols.
机构信息
Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, PR China.
出版信息
Org Lett. 2012 Dec 21;14(24):6198-201. doi: 10.1021/ol3029498. Epub 2012 Dec 10.
PMID:23228044
Abstract
AuCl(3)-catalyzed reaction of 1-(indol-2-yl)-3-alkyn-1-ols occurred smoothly in toluene at room temperature to form a benzene ring leading to a series of carbazole derivatives efficiently. A possible mechanism has been proposed for the formation of carbazoles.
摘要
AuCl(3)-催化的 1-(吲哚-2-基)-3-炔-1-醇在甲苯中的室温反应顺利进行，形成苯环，有效地生成了一系列咔唑衍生物。提出了一种形成咔唑的可能机制。
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